The diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant impairs glucose-stimulated insulin response in 5,722 non-diabetic Danish individuals

N. Grarup; M. Overvad; T. Sparsø; D. R. Witte; C. Pisinger; T. Jørgensen; T. Yamauchi; K. Hara; S. Maeda; T. Kadowaki

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The diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant impairs glucose-stimulated insulin response in 5,722 non-diabetic Danish individuals

机译：糖尿病患者的VPS13C / C2CD4A / C2CD4B rs7172432变体损害了5,722名非糖尿病丹麦个体的葡萄糖刺激的胰岛素反应

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Aims/hypothesis A genome-wide association study in the Japanese population reported two genome-wide significant loci associated with type 2 diabetes of which the VPS13C/C2CD4A/C2CD4B locus was replicated in Europeans. We looked for potential associations between the diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant and diabetes-related intermediary traits.

机译：目的/假设日本人群中的全基因组关联研究报告了两个与2型糖尿病相关的全基因组重要基因座，其中VPS13C / C2CD4A / C2CD4B基因座在欧洲人中复制。我们寻找了致糖尿病的VPS13C / C2CD4A / C2CD4B rs7172432变体与糖尿病相关的中介性状之间的潜在关联。

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《Diabetologia》 |2011年第4期|p.789-794|共6页
作者
N. Grarup; M. Overvad; T. Sparsø; D. R. Witte; C. Pisinger; T. Jørgensen; T. Yamauchi; K. Hara; S. Maeda; T. Kadowaki;
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正文语种 eng
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Genetic epidemiology – Genetics – Insulin response – Type 2 diabetes;

机译：遗传流行病学–遗传学–胰岛素反应– 2型糖尿病;

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机译：DGKB / TMEM195，ADRA2A，GLIS3和C2CD4B基因座的变异与丹麦中年人葡萄糖刺激的β细胞功能降低有关
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5. The diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant impairs glucose-stimulated insulin response in 5,722 non-diabetic Danish individuals [O] . Grarup N., Overvad Maria, Sparsø T., 2011

机译：糖尿病患者的VPS13C / C2CD4A / C2CD4B rs7172432变体损害了5,722名非糖尿病丹麦个体的葡萄糖刺激的胰岛素反应

The diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant impairs glucose-stimulated insulin response in 5,722 non-diabetic Danish individuals

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