rs1004819 Is the Main Disease-Associated IL23R Variant in German Crohns Disease Patients: Combined Analysis of IL23R CARD15 and OCTN1/2 Variants

摘要

BackgroundThe IL23R gene has been identified as a susceptibility gene for inflammatory bowel disease (IBD) in the North American population. The aim of our study was to test this association in a large German IBD cohort and to elucidate potential interactions with other IBD genes as well as phenotypic consequences of IL23R variants.