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  • 机译 赞比亚的en虫病防治:通往成功的坎road之路
    摘要:The taeniosis/cysticercosis neglected zoonotic disease complex is caused by Taenia solium, and is associated with significant economic and public health impacts. This paper reviews the current knowledge on T. solium in Zambia and the control strategies already studied, covering almost 20 years of research, and explores the way forward. Studies on occurrence of porcine cysticercosis indicated very high prevalences, ranging from 15 to 34% based on detection of circulating antigens, and of 46% to 68% based on full carcass dissection in slaughter age pigs. Taeniosis prevalences have been reported to range from 6.3% to 12% based on copro-Ag-ELISA. Human cysticercosis prevalence results ranged from 5.8% to 13% based on serum Ag-ELISA, and from 34% to 39% based on sero-antibody detection. Later on, a study in people with epilepsy suggested neurocysticercosis to be the single most important cause of epilepsy in this T. solium endemic area, with 57% of the people with active epilepsy diagnosed with probable or definite neurocysticercosis. While the need to reduce the disease burden of T. solium in Zambia is obvious, the exact short and long term goals, and the strategies to achieve these goals, are not clear. We have selected the most promising control/elimination strategies from reviews and assessed these for feasibility via discussions with local stakeholders from both medical and veterinary sectors. The proposed measures were evaluated using the newly developed agent-based disease transmission model, cystiSim and optimised using Zambian demographic and disease data. As a control option, yearly porcine treatments were selected as best option, while the preferred strategy for elimination was determined to be the combination of human and porcine mass drug administration combined with porcine vaccination of all eligible people and pigs, in a schedule of six iterations of four monthly interventions. These interventions are currently being field tested, combined with education. Several other hurdles to control, such as cost and socio-political factors and the need for an improved advocacy and awareness creation are discussed.
  • 机译 亚洲研究控制蠕虫病的可能性,挑战和新方法
    摘要:The time is passing, and the worms are still a major struggle for local people in Asian countries, especially the less empowered and in a situation of social vulnerability. We are working in the field in Laos, Thailand, and the Philippines where the usual control programs based only on human treatment are partially effective. Areas with mass drug administration could diminish, but not eliminate STHs of endemic areas. The persistence of helminthic NTDs in the environment and animal hosts makes the eradication a very difficult task. Great changes in the landscapes of endemic areas, such as construction of dams, can change the fauna and the lifestyle of local people. Those changes can improve infrastructure, but it can also lead to social vulnerability. The challenge, then, is to conceive new and directed control programs for helminthiasis based on multi- and transdisciplinary approaches diminishing the health gap in a globalized world. In this short review, we summarize the actual scenario concerning the main helminths in Southeast Asia and how an environmental DNA approach and the use of GIS could contribute to surveillance and control programs.
  • 机译 跨学科和社会生态健康框架-新型方法应对新兴的寄生虫和媒介传播疾病
    摘要:Ecosystem Health, Conservation Medicine, EcoHealth, One Health, Planetary Health and GeoHealth are inter-related disciplines that underpin a shared understanding of the functional prerequisites of health, sustainable vitality and wellbeing. All of these are based on recognition that health interconnects species across the planet, and they offer ways to more effectively tackle complex real-world challenges. Herein we present a bibliometric analysis to document usage of a subset of such terms by journals over time. We also provide examples of parasitic and vector-borne diseases, including malaria, toxoplasmosis, baylisascariasis, and Lyme disease. These and many other diseases have persisted, emerged or re-emerged, and caused great harm to human and animal populations in developed and low income, biodiverse nations around the world, largely because of societal drivers that undermined natural processes of disease prevention and control, which had developed through co-evolution over millennia. Shortcomings in addressing drivers has arisen from a lack or coordinated efforts among researchers, health stewards, societies at large, and governments. Fortunately, specialists collaborating under transdisciplinary and socio-ecological health umbrellas are increasingly integrating established and new techniques for disease modeling, prediction, diagnosis, treatment, control, and prevention. Such approaches often emphasize conservation of biodiversity for health protection, and they provide novel opportunities to increase the efficiency and probability of success.
  • 机译 哥斯达黎加绵羊的弓形虫和犬新孢子虫的血清感染率及相关因素
    摘要:The presence of antibodies against Toxoplasma gondii and Neospora caninum were analyzed in 392 sheep sera from ten Costa Rican ovine flocks using indirect immuno-enzymatic assays. Additionally, general information about sheep management, environment, and clinical reproductive disorders was assessed through a questionnaire to inquire factors related to these apicomplexan parasites. A total of 161 (41.1%) serum samples reacted positive to T. gondii, 43 (10.9%) to N. caninum and 26 (6.63%) to both parasites. Toxoplasma gondii serorreactors were detected in all the analyzed flocks (100.0%), meanwhile N. caninum antibodies were found in nine flocks (90%), from the six Costa Rican regions. Factors associated with T. gondii were the co-presence of cattle (OR = 5.06; C.I.95%; 2.08–12.30; p: <0.001), grey foxes (Urocyon cinereoargenteus) and opossums (Didelphis marsupialis) (OR = 2.44; C.I.95%; 1.50–3.95; p: <0.001) inside or around the farms, and the presence of peccaries (Tayassu sp.) (OR = 0.35; C.I.95%; 0.16–0.74; p: 0.0058) was a variable associated with N. caninum seropositivity. The obtained results of T. gondii and N. caninum infections in sheep flocks from Costa Rica should be considered for the proper prevention and control strategies against these apicomplexan abortive parasites.
  • 机译 观点:寄生虫和伙伴关系
    摘要:This text grew from a series of talks between a young science journalist trained in history and Marcel Tanner, global health expert with forty years of field experience in many countries in sub-Saharan Africa and Asia. At the very core of the series was the question of the successes and failures of global health initiatives at various points in time and in different locations. It also tackled the issue of which of the lessons learned in global health over the past thirty years could possibly be of importance for future scholars and decision-makers in the field. The topics touched upon ranged from new global partnerships to sustain the efforts to eradicate malaria and other diseases to new innovations in personalised health, not least for the world's most neglected populations. The views expressed here are based on scientific findings as well as personal experiences and hence are also inherently subjective. Having said this, we still hope that the rich body of evidence assembled over years of extensive field-work and research partnership is of some value to all those how still dare to embark on the adventure of global health research in a spirit of “mutual learning for change.”
  • 机译 寄生虫损失或寄生虫获得?对立水域中线虫的故事
    • 作者:Shokoofeh Shamsi
    • 刊名:Parasite Epidemiology and Control
    • 2019年第期
    摘要:Contracaecum spp. are parasitic nematodes belonging to the family Anisakidae. They are known to be able to have highly pathogenic impacts on both wildlife (fish, birds, marine mammals) and humans. Despite having the most numerous species of any genus of Anisakidae, and despite a wide range of publications on various aspects of their pathogenicity, biology and ecology, there are no recent comprehensive reviews of these important parasites, particularly in the Southern Hemisphere. In this article, the diversity of Contracaecum parasites in Australian waters is reviewed and possible anthropological impacts on their populations are discussed. The abundance and diversity of these parasites may have been under-reported due to the inadequacy of common methods used to find them. Populations of Contracaecum parasites may be increasing due to anthropogenic factors. To minimise the risk these parasites pose to public health, preventive education of stakeholders is essential. There are still many unknown aspects of the parasites, such as detailed information on life cycles and host switching, that will be interesting directions for future studies.
  • 机译 墨西哥尤卡坦州廷努姆市利什曼原虫感染的初步流行病学发现
    摘要:Localized cutaneous leishmaniasis (LCL) is endemic in Mexico, mainly in the states of Campeche and Quintana Roo, hyperendemic areas of Leishmania (Leishmania) mexicana transmission. In this report, epidemiological features of Leishmania infections in the municipality of Tinum, Yucatan State, Mexico are presented. Nine cases of LCL were diagnosed in 2015. Patients were men between 30 and 74 years of age, without a history of living or traveling to endemic areas (Quintana Roo or Campeche). Due to asymptomatic infection is the most common outcome after Leishmania inoculation, between November 2017 to June 2018, 47 men working in the forest were tested by Montenegro skin test (MST). Thirteen of them (27.6%) were identified MST positive, in absence of either lesion or typical scar, and evidence of exposure to vector. Findings in Tinum, Yucatan, supported the presence of specific environmental conditions that seem to favor Leishmania transmission in this region. Thus, active surveillance for the detection of new cases in the municipality of Tinum as well as the eco-epidemiological characterization to identify all the transmission components (parasite, vector, and reservoir species) are urgently needed.
  • 机译 摩洛哥Tadla-Azilal病区皮肤利什曼病的30年
    摘要:Cutaneous leishmaniasis (CL) due to Leishmania tropica is a major health problem in Tadla-Azilal focus, Morocco, where the first case was registered, here, in one locality named Tanant in 1987. So far, CL remains endemic and largely widespread. The objective of this study was to analyze the current eco-epidemiological situation after thirty years of active transmission. Data used are the official ones, obtained from the Moroccan Ministry of Health.Between 1998 and 2015, 5518 CL cases were registered in three provinces; Azilal, Béni Mellal and Fquih Ben Salah. CL has spread, from the historical focus in Azilal along two axes; one to the Northeastern Mountains and the other to the Northwestern plains.CL infected both genders and all ages, with large number of women (53%) and children (75% had <9 years old). More interestingly, age range at risk was larger within females than males, and this difference was more pronounced in Fquih Ben Salah where the disease had newly emerged. Similarly, age ranges at risk were larger and fluctuated significantly each year particularly in new emerging areas in Béni Mellal and Fquih Ben Salah. All these variations may testify, at least in part, to the process of acquiring immunity.Altitude structured CL spatiotemporal distribution. CL was more prevalent in two altitudes ranges; 400–500 m and 800–900 m. The situation and duration of period of diagnostic of CL varied largely according to the altitude. These different scenarios could be related to the seasonal dynamics of vector populations.
  • 机译 马来布鲁氏菌丰富幼虫蛋白transcript-2(BmALT-2)和塔夫辛融合蛋白在实验小鼠模型中的免疫学评价
    摘要:IntroductionFilariasis, a neglected tropical helminth disease needs vaccine besides mass drug administration for its successful eradication.
  • 机译 Ta虫的循环抗原的检测。在肯尼亚内罗毕及周边地区被宰杀供食用的猪
    摘要:Background & methodsTaenia solium a zoonotic tapeworm, responsible for neurocysticercosis in humans is a major public health threat, being a leading cause of acquired epilepsy in endemic regions. Eastern and southern African nations have experienced a recent rapid growth in pig production, including small-scale, free-range systems, with an accompanying increased risk of T. solium transmission. Seven hundred blood samples were collected from randomly selected pigs presented for slaughter at one of the largest porcine abattoir supplying unprocessed pork to Nairobi city and its surroundings. The samples were tested using an antigen ELISA to determine the prevalence of infection with Taenia spp.
  • 机译 摩洛哥Gharb平原的绵羊Haemonchus contortus寄生虫调查
    摘要:The study was designed to determine the prevalence of Haemonchus contortus, intestinal helminthes parasite of sheep in the Gharb plain (Morocco).A total of 1154 sheep were randomly selected from farms, pastures and abattoirs, the samples were examined using a flotation techniques for determination the eggs of Haemonchus contortus. In order to identify Haemonchus contortus among the different gastrointestinal strongyles present in mixed infections, a faecal culture was carried out for each farm and pasture. This study was carried between November 2016 and October 2017. The data were analysed with respect to sex, age, season and body condition of sheep examined. Out of (1154) samples examined, (23.92%) harbored H. contortus. Prevalence among female (30.98%) was higher than that of the males (15.63%), there was significant difference between prevalence of infection and sex (P < 0.05). Based on age group, prevalence of haemonchosis was 6.25% and 43.22% in young and aged animals respectively showing the statistical significance (P < 0.05). Seasonal variation was recorded throughout the year and was highest during spring (36.36%) and autumn (32.37%) against a low rate of 2.7% in the summer with significance difference (P < 0.05). Regarding the relationship between Haemonchosis contortus and body condition, maximum prevalence (80.83%) was recorded in animals with poor body condition, followed by those with moderate body condition (34.26%), while the lowest infestation rate (6.88%) is noted in animals with good body.
  • 机译 秘鲁流行区通过高分辨率融解和巢式PCR鉴定具有不同临床表现的患者活检中的利什曼原虫种类
    摘要:BackgroundThe parasite of the genus Leishmania causes a neglected disease known as leishmaniasis, which has different clinical aspects depending on the species that infects the person and the immune response of the patient. The objective was to determine, using molecular biology, the current circulating species of Leishmania in biopsies of different types of cutaneous leishmaniasis (CL) from the endemic district in the region of “Madre de Dios”, Peru.
  • 机译 阿根廷布宜诺斯艾利斯省农村地区孕妇与城郊生活场所相关的弓形虫血清阳性
    摘要:Infection with is very common in humans throughout the world, the intake of raw or undercooked meat with tissue cysts and fruits, vegetables and water contaminated with parasite oocysts being the main routes of infection. Here, we analyzed the seroprevalence of - antibodies in pregnant females (age 13–44 years; n = 920) between April 2014 and December 2017 from Chascomús (Argentina), a city immersed in a rural area. Altogether 320 tested positive for immunoglobulin G antibodies, yielding an overall seroprevalence of 34.8% (CI 95%: 31.7–37.9). No association was observed between seropositivity and age. In addition, by using the QGIS 3.2.1 software we analyzed the geographical distribution of 769 (83.6%) pregnant females in two main areas of the city: Urban (n = 157) and Peri-urban (n = 612) with a seroprevalence of 26.8% (CI 95%: 19.8–33.7) and 36.4% (CI 95%: 32.6–40.3) respectively, and this difference was statistically significant (p = 0.023). Furthermore, we assessed through a questionnaire survey, between April 2016 to December 2017, possible risk factors such as activity (urban and rural), home water supply, animal husbandry, presence of cats as pets, gardening and consumption of meat and its derivatives (pork, sheep meat and sausages) and their frequencies (consumption per week), not finding significant association with seropositivity. Significant differences was found when the seroprevalence was analyzed between the urban and peri-urban neighborhoods of the city of Chascomús. The higher seroprevalence in peri-urban neighborhoods could be due to an unfavorable socioeconomic situation and/or to undeveloped peri-urban environments, which is a risk factor that should be taken into account when planning the health care of pregnant females.
  • 机译 坦桑尼亚Kongwa地区猪中循环中的牛带eni抗原的血清阳性率及相关危险因素
    摘要:The aim of this study was to investigate exposure to porcine cysticercosis (PC) and associated risk factors in the Kongwa District, eastern-central Tanzania. For the first time a cross-sectional investigation of the seroprevalence in pigs using a commercial genus specific cysticercosis enzyme linked immunosorbent assay (apDia Ag-ELISA) was undertaken in eastern-central Tanzania. Moreover, the identity of suspected cysts from pigs in the study area were confirmed by sequencing parasites’ mitochondrial gene. Structured questionnaires and direct observations were used to investigate risk factors associated with parasite transmission. A total of 102 pig-keeping households were surveyed during the dry season between July and August 2017 and 126 households in the rainy season between March and April 2018. Of the 447 examined pigs, 77 (17%, 95% C.I. 14%–20%) tested positive in the ELISA. Seroprevalence was higher in pigs examined during the rainy (21%, 95% C.I. 16%–26%) than dry (12%, 95% C.I. 7%–17%) season (p = 0.019). Eight cyst-positive-pigs were confirmed to be infected with by sequencing. Risk factors associated with PC seropositivity included origin of piglets or pigs (OR = 0.27, 95% C.I. 0.13–0.42, p = 0.001), socioeconomic factors and pig production system (OR = 0.22, 95% C.I. 0.07–0.37, p = 0.005) and sanitation and hygiene practices (OR = 0.19, 95% C.I. 0.04–0.34, p = 0.014). This study has recorded a high spp. seroprevalence in pigs in Kongwa suggesting the presence of people in the community carrying the adult parasite, . Our findings also suggest risk of infection by to people in urban centres and cities consuming pigs from rural areas in Kongwa. The high seroprevalence in Kongwa calls for further studies on taeniasis and cysticercosis in the human population in order to determine suitable control strategies.
  • 机译 菲律宾某些有机农场和传统农场的土壤传播蠕虫(STH)卵污染土壤
    摘要:Soils from selected organic and conventional farms in the Philippines were examined for parasite contamination. A total of 600 soil samples from twenty organic and conventional farms were collected and processed through modified sucrose floatation technique. Results revealed that 248 out of 600 (41.33%) soil samples were contaminated with parasite eggs. Parasites recovered were spp. (39.0%), spp. (26.0%), hookworm/strongylid (22.0%), spp. (4.0%), spp. (3.0%), and some unidentified eggs (6.0%). Contamination rate was found higher in organic (48.30%) than in conventional farms (37.67%) (  = 0.834; not significant); and significantly higher in Southern (64.40%) than in Northern Luzon region (31.40%) (  = 0.015). In addition, contamination rate between soil depths was not statistically significant (  = 0.24), with depth 1 (0-5 cm) at 43% and depth 2 (6-10 cm) at 39.67%. Furthermore, some farming practices were recorded through survey and results revealed that the use of manure as fertilizer (  = 0.017) and wash water (  = 0.014) showed significant positive relationship with parasite contamination in soil. These findings have implications on food safety and could be used to help the agriculture sector and other stakeholders in their efforts to improve food safety policies.
  • 机译 老挝人民民主共和国中部三个省的母子对中的蠕虫感染率很高
    摘要:In Southeast Asia, the large majority of the population remains affected by parasitic worms despite longstanding mass treatment and health education campaigns. Soil-transmitted helminths and also the fish-borne liver fluke negatively affect development during early childhood.
  • 机译 Blastocystis sp。的亚型的表征。分离自荨麻疹患者,巴西圣保罗
    摘要:sp. is described as an enteric protist prevalent in fecal samples from humans and animals; its pathogenicity and epidemiology are still controversial. Currently, it has been associated with intestinal diseases such as irritable bowel syndrome and clinical manifestations of allergic skin, such as chronic urticaria. In the context of urticaria, it is still uncertain whether this organism is directly related to the allergic manifestation or just a common component of the intestinal microbiota. This study aimed to evaluate the occurrence and molecular diversity of sp. in individuals with urticaria from a dermatology outpatient clinic, São Paulo, Brazil. Fecal samples of 58 patients with urticaria were examined using parasitological methods; and subsequently tested by polymerase chain reaction using -specific primers. The subtypes (STs) and alleles (a) were determined using BLASTn and MLST tools. ST1, ST2, ST3, ST4, ST6 and mixed infection (ST1 + ST3) were identified in the patients with urticaria; ST1 (a4), ST3 (a34 and a36) and ST4 (a42) were the most prevalent. Our molecular analyses allowed an initial description of subtypes in patients with urticaria from São Paulo city, Brazil.
  • 机译 加纳博莱地区农业社区易感疟疾
    摘要:Malaria contributes substantially to the poor health situation in the northern region of Ghana, especially in the Bole district. This paper is an outcome of a study, which assessed the factors that influenced the vulnerability of farming households to malaria, as well as the economic burden of the malaria prevalence in the Bole District, Ghana. The multiple linear regression model was used to analyze the determinants of household's vulnerability to malaria, and to examine the relationship between the non-parametric dependent variable and dichotomous independent variables. The outcome of the study revealed an increase in malaria cases during the rainy season. Total direct cost of malaria care, number of people comprising the farming household, support for malaria prevention, information on mosquito breeding and development, and absenteeism from farm emerged as the main factors, which influenced the households' vulnerability to malaria. Direct and indirect costs of malaria treatment have negatively affected the households' budget. In addition, malaria treatment cost represented a substantial portion of poor farming household income. The direct cost was estimated to GH₵ 4059, and the indirect cost was estimated to GH₵ 4654. It was recommended to the government of Ghana to expand the National Malaria Control Program to the household level and make National Health Insurance Scheme more efficient.
  • 机译 关于尼日利亚西南部伊巴丹土壤传播的蠕虫污染土壤的知识,态度和实践
    摘要:Ancylostoma duodenale, Necator americanus, Ascaris lumbricoides and Trichuris trichiura, the four major Soil-transmitted helminths (STHs) and also Strongyloides stercoralis infect humans worldwide. Most studies on Soil-transmitted helminths (STHs) carried out in Ibadan were faecal examination based while relatively few soil examination based studies were carried out mostly around school premises using limited number of sampling locations. This study was therefore designed to assess the level of soil contamination with STH and associated risk factors in the eleven local government areas of Ibadan. A total of 1980 soil samples were purposively collected monthly, between January and December 2017, from toilet areas, refuse dump sites, house vicinities, playgrounds, roadsides/walk ways, and examined for the presence of parasite eggs or larvae using automated analysis of light microscopy images by computer. Well-structured questionnaires were administered to 620 consenting participants to obtain information on the Knowledge of STH infections, Attitudes and Practices towards the infections. Data were analyzed using SPSS version 21, Chi-square and ANOVA were used in the analysis at p < 0.05. Out of soil samples examined, 1087 (54.9%) had at least one species of parasite. The prevalence of hookworm was 74.5% followed by 50.2% and 37.2% for Strongyloides species larvae and adult respectively, and 25.1% for Ascaris species. The highest prevalence was observed in the refuse dump (74.2%) followed by toilet area (36.5%) while the lowest was at house vicinities (1.6%). Fifty-seven percent of the respondents use pit latrine while 20.6% still practice open defecation. A high transmission risk was observed as large percentage (66.8%) of the respondents showed inadequate knowledge of how to avoid STH infections. Moreover, 64.0% and 25.2% reported that they often walk barefooted and suck fingers respectively. The high prevalence of parasitic contamination of soil observed in the present study and the high proportion of respondent with inadequate knowledge of how to prevent transmission of STH pose a high risk of re-infections in the study area even after treatment. Therefore there is a need for proper education on parasite transmission in the area.
  • 机译 埃塞俄比亚西南部马尾类胃肠道寄生虫的横断面研究
    摘要:A cross sectional study was conducted in Jimma town from October 2010 to March 2011 with the objective of determining the status of intestinal nematode parasites of equids, and the association of different variables with infection rate. To address this, a total of 400 equids; donkeys (n = 29), horses (n = 317) and mules (n = 54) were used in this study and based on the coprological examination to identify parasite eggs, three species of nematodes were identified with an overall prevalence of 72.25%. A prevalence of 63.25%, 16.50%, 4.25%, and 10.75% were identified for Strongyles, Parascaris equorum, Oxyuris equi, and mixed infection respectively. Highest to lowest prevalence of Strongyles (63.72, 51.85 and 79.31%), P. equorum (17.98, 12.96 and 6.89%) and O. equi (5.04, 1.85 and 0.00%) were observed in horse, mule and donkey, respectively. The statistical analysis between the species of equine and strongyle infection rate, body condition scores with strongyle and P. equorum infection rate (p < 0.05). However, species of the animal was not significantly associated with P. equorum (p < 0.05). The infection rate of O. equi was not significantly associated with body condition score, age and species of equines (p > 0.05 for all variables) and no significant difference (p > 0.05) between the prevalence of intestinal nematodes and sex of the animal was showed. Therefore, the present study revealed that intestinal nematodes are an important health problem in the area affecting the wellbeing and productivity of equids.

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