2036. Plasma (1→3)-β-D-Glucan Levels Correlate with Neurocognitive Functioning in HIV-Infected Adults

摘要

BackgroundAlthough antiretroviral therapy (ART) has improved survival and morbidity, HIV-infected adults still have higher rates of non-AIDS disorders, such as neurocognitive impairment, than HIV-uninfected adults. (1–3)-b-D-Glucan (BDG) is a fungal cell wall component which serves as a plasma biomarker for fungal infection and—in the absence of fungal infections—for gut barrier integrity failure and microbial translocation. The objective of this study was to determine whether higher plasma and cerebrospinal fluid (CSF) levels of BDG are associated with neurocognitive impairment [evaluated by global deficit score (GDS)] in HIV-infected adults.