2053. Tissue-Based Molecular Diagnostics: A Sensitive and Specific Way for the Identification of Invasive Fungal Infections in the Combat-Related Setting

摘要

BackgroundCombat-associated invasive fungal infections (IFI) of the deep skin and soft tissue are an infectious disease. Reliance on conventional techniques to diagnose IFIs has limitations as culture is insensitive and time-delayed and histopathology cannot provide a species-level or even a genus-level identification (ID). Molecular-based methods are rapid, provide species-level ID, and have been studied to a limited extent in the trauma setting although they may prove overly sensitive as soil (thereby fungal) contamination is common. In this study, we examined the performance characteristics of a panfungal PCR for the diagnosis of IFI among subjects injured in Afghanistan operations.