1586. In Vitro Activity of Rifampin Rifabutin Rifapentine and Rifaximin Against Biofilms Formed by Staphylococci Isolated from Prosthetic Joint Infection

摘要

BackgroundProsthetic joint infections (PJIs) are serious complications after total joint arthroplasty. Staphylococcus aureus and Staphylococcus epidermidis, which are proficient biofilm-formers, account for ~60% of PJI cases. Therapy often includes rifampin because of its anti-biofilm activity; the activity of other rifamycins against staphylococcal biofilms is poorly defined. This study evaluated the in vitro activity of rifampin, rifabutin, rifapentine, and rifaximin against S. aureus and S. epidermidis biofilms formed by isolates from patients with PJI.