…once the development was ended, the founts of growth and regeneration of the axons and dendrites dried up irrevocably. Santiago Ramón y Cajal
…once the development was ended, the founts of growth and regeneration of the axons and dendrites dried up irrevocably. Santiago Ramón y CajalCajal’s neurotropic theory postulates that the complexity of the nervous system arises from the collaboration of neurotropic signals from neuronal and non-neuronal cells and that once development has ended, a paucity of neurotropic signals means that the pathways of the central nervous system are “fixed, ended, immutable”. While the capacity for regeneration and plasticity of the central nervous system may not be quite as paltry as Cajal proposed, regeneration is severely limited in scope as there is no spontaneous regeneration of long-distance projections in mammals and therefore limited opportunity for functional recovery following spinal cord injury. It is not a far stretch from Cajal to hypothesize that reappropriation of the neurotropic programs of development may be an appropriate strategy for reconstitution of injured circuits. It has become clear, however, that a significant number of the molecular cues governing circuit development become re-active after injury and many assume roles that paradoxically obstruct the functional re-wiring of severed neural connections. Therefore, the problem to address is how individual neural circuits respond to specific molecular cues following injury, and what strategies will be necessary for instigating functional repair or remodeling of the injured spinal cord.Electronic supplementary materialThe online version of this article (doi:10.1007/s13311-015-0416-0) contains supplementary material, which is available to authorized users.
…一旦开发结束,轴突和树突生长和再生的源头就不可避免地干dried了。 SantiagoRamóny Cajal blockquote> Cajal的神经质理论认为,神经系统的复杂性来自神经元和非神经元细胞的神经质信号的协作,一旦发育结束,神经质信号的匮乏意味着中枢神经系统是“固定的,终结的,不变的”。虽然中枢神经系统的再生能力和可塑性可能不如Cajal所建议的那么微不足道,但再生的范围受到严重限制,因为哺乳动物的远距离投射没有自发再生,因此脊柱后功能恢复的机会有限脐带受伤。从卡哈尔(Cajal)出发,假想重新适应神经发育计划可能是重建受损回路的合适策略,这并非遥不可及。然而,已经清楚的是,支配电路发展的大量分子线索在受伤后会重新反应,许多承担起矛盾的作用,从而切断了切断的神经连接的功能。因此,要解决的问题是单个神经回路如何对受伤后的特定分子线索做出反应,以及为促进受损脊髓的功能性修复或重塑需要采取哪些策略。电子补充材料本文的在线版本(doi:10.1007 / s13311-015-0416-0)包含补充材料,授权用户可以使用。
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