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p53-targeted lincRNA-p21 acts as a tumor suppressor by inhibiting JAK2/STAT3 signaling pathways in head and neck squamous cell carcinoma

机译：p53靶向的lincRNA-p21通过抑制头颈部鳞状细胞癌中的JAK2 / STAT3信号传导通路而充当肿瘤抑制因子

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BackgroundLong intergenic noncoding RNA p21 (lincRNA-p21) is considered a target of wild-type p53, but little is known about its regulation by mutant p53 and its functions during the progression of head and neck squamous cell carcinoma (HNSCC).

机译：背景长的非基因间非编码RNA p21（lincRNA-p21）被认为是野生型p53的靶标，但对于突变型p53的调控及其在头颈部鳞状细胞癌（HNSCC）进程中的功能知之甚少。

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期刊名称 Molecular Cancer
作者
Shufang Jin; Xi Yang; Jiayi Li; Wenyi Yang; Hailong Ma; Zhiyuan Zhang;
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作者单位

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年(卷),期 2019(18),
年度 2019
页码 38
总页数 18
原文格式 PDF
正文语种
中图分类分子生物学;肿瘤学;
关键词
Long intergenic noncoding RNA p21, p53, NF-YA, Signal transducer and activator of transcription 3, Head and neck squamous cell carcinoma;

机译：长基因间非编码RNA p21;p53;NF-YA;信号转导子和转录激活子3;头颈部鳞状细胞癌;

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专利

1. Carbon Ion Therapy Inhibits Esophageal Squamous Cell Carcinoma Metastasis by Upregulating STAT3 Through the JAK2/STAT3 Signaling Pathway [J] . Hongtao Luo, Xiaohu Wang, Zhen Yang, Frontiers in Public Health . 2020,第a期

机译：通过JAK2 / Stat3信号通路上调STAT3，碳离子疗法抑制食道鳞状细胞癌转移
2. Carbon Ion Therapy Inhibits Esophageal Squamous Cell Carcinoma Metastasis by Upregulating STAT3 Through the JAK2/STAT3 Signaling Pathway [J] . Luo Hongtao, Yang Zhen, Zhang Qiuning, Frontiers in Public Health . 2020,第2期

机译：通过jak2 / stat3信号通路上调stat3，碳离子疗法通过上调STAT3来抑制食道鳞状细胞癌转移
3. Promoter methylation of MGMT, MLH1 and RASSF1A tumor suppressor genes in head and neck squamous cell carcinoma: Pharmacological genome demethylation reduces proliferation of head and neck squamous carcinoma cells [J] . KoutsimpelasD., PongsapichW., HeinrichU., Oncology reports . 2012,第4期

机译：头颈部鳞状细胞癌中MGMT，MLH1和RASSF1A抑癌基因的启动子甲基化：药理基因组去甲基化可降低头颈部鳞状细胞的增殖
4. siRNA inhibits esophageal squamous cell carcinoma cell lines growth via NF-κB signaling pathway [C] . Fang Tian, Lexun Xue, Weidong Zang, International Symposium on Interdisciplinary Life Sciences: From Genome to Function . 2005

机译：siRNA通过NF-κB信号通路抑制食管鳞状细胞癌细胞系的生长
5. Analysis of CXCL12/SDF-1alpha mediated activation of the NF-kappaB signaling pathway in head and neck squamous cell carcinoma. [D] . Rehman, Aasia O. 2009

机译：CXCL12 / SDF-1alpha介导的头颈部鳞状细胞癌中NF-κB信号通路的激活分析。
6. Dihydroartemisinin as a Putative STAT3 Inhibitor, Suppresses the Growth of Head and Neck Squamous Cell Carcinoma by Targeting Jak2/STAT3 Signaling [O] . Lifeng Jia, Qi Song, Chenyang Zhou, 2011

机译：双氢青蒿素作为一种可能的STAT3抑制剂，通过靶向Jak2 / STAT3信号传导抑制头颈部鳞状细胞癌的生长
7. Dihydroartemisinin as a Putative STAT3 Inhibitor, Suppresses the Growth of Head and Neck Squamous Cell Carcinoma by Targeting Jak2/STAT3 Signaling. [O] . Lifeng Jia, Qi Song, Chenyang Zhou, 2016

机译：双氢青蒿素作为推定的sTaT3抑制剂，通过靶向Jak2 / sTaT3信号抑制头颈部鳞状细胞癌的生长。

p53-targeted lincRNA-p21 acts as a tumor suppressor by inhibiting JAK2/STAT3 signaling pathways in head and neck squamous cell carcinoma

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