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Regulation of DNA methyltransferase 1 transcription in BRCA1-mutated breast cancer: a novel crosstalk between E2F1 motif hypermethylation and loss of histone H3 lysine 9 acetylation

机译：在BRCA1突变的乳腺癌中DNA甲基转移酶1转录的调节：E2F1母题超甲基化和组蛋白H3赖氨酸9乙酰化丧失之间的新型相声

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摘要

BackgroundDNA methyltransferase 1 (DNMT1) plays a critical role in breast cancer progression. However, the epigenetic mechanism regulating DNMT1 expression remains largely unknown.

机译：背景DNA甲基转移酶1（DNMT1）在乳腺癌的进展中起着至关重要的作用。但是，调节DNMT1表达的表观遗传机制仍然未知。

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期刊名称 Molecular Cancer
作者
Da Li; Fang-Fang Bi; Ji-Min Cao; Chen Cao; Bo Liu; Qing Yang;
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作者单位

展开▼
年(卷),期 1971(13),
年度 1971
页码 26
总页数 12
原文格式 PDF
正文语种
中图分类分子生物学;肿瘤学;
关键词
DNMT1, Histone modifications, E2F1, BRCA1, Breast cancer;

机译：DNMT1;组蛋白修饰;E2F1;BRCA1;乳腺癌;

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专利

1. Regulation of DNA methyltransferase 1 transcription in BRCA1-mutated breast cancer: a novel crosstalk between E2F1 motif hypermethylation and loss of histone H3 lysine 9 acetylation [J] . Da Li, Fang-Fang Bi, Ji-Min Cao, Molecular Cancer . 2014,第2期

机译：调节BRCA1突变的乳腺癌中DNA甲基转移酶1转录的调控：E2F1基序高甲基化与组蛋白H3赖氨酸9乙酰化丧失之间的新型串扰
2. Loss of DNA methylation and histone H4 lysine 20 trimethylation in human breast cancer cells is associated with aberrant expression of DNA methyltransferase 1, Suv4-20h2 histone methyltransferase and methyl-binding proteins. [J] . Tryndyak VP, Kovalchuk O, Pogribny IP Cancer biology & therapy . 2006,第1期

机译：人乳腺癌细胞中DNA甲基化和组蛋白H4赖氨酸20三甲基化的丧失与DNA甲基转移酶1，Suv4-20h2组蛋白甲基转移酶和甲基结合蛋白的异常表达有关。
3. Trimethylation of histone H3 lysine 4 impairs methylation of histone H3 lysine 9: regulation of lysine methyltransferases by physical interaction with their substrates. [J] . Binda O, LeRoy G, Bua DJ, Epigenetics: official journal of the DNA Methylation Society . 2010,第8期

机译：组蛋白H3赖氨酸4的三甲基化会损害组蛋白H3赖氨酸9的甲基化：赖氨酸甲基转移酶通过与底物的物理相互作用进行调节。
4. SAHA Treatment Reveals the Link between Histone Lysine Acetylation and Proteome in Non-small Cell Lung Cancer A549 Cells [C] . Quan Wu, Weiqing Xu, Lejie Cao, ASMS Conference on Mass Spectrometry and Allied Topics . 2014

机译：Saha治疗揭示了非小细胞肺癌A549细胞中组蛋白赖氨酸乙酰化和蛋白质组之间的联系
5. Regulation of human cytomegalovirus gene expression by changes in histone H3 acetylation and methylation, and through binding of transcription factors to promoter regions during replication in fibroblasts. [D] . Cuevas, Christian David. 2009

机译：通过组蛋白H3乙酰化和甲基化的变化以及成纤维细胞复制过程中转录因子与启动子区域的结合来调节人类巨细胞病毒基因表达。
6. Poly (ADP-ribose) polymerase 1 transcriptional regulation: A novel crosstalk between histone modification H3K9ac and ETS1 motif hypomethylation in BRCA1-mutated ovarian cancer [O] . Da Li, Fang-Fang Bi, Ji-Min Cao, 2014

机译：聚（ADP-核糖）聚合酶1转录调控：BRCA1突变的卵巢癌中组蛋白修饰H3K9ac和ETS1基序低甲基化之间的新型串扰。
7. Regulation of DNA methyltransferase 1 transcription in BRCA1-mutated breast cancer: a novel crosstalk between E2F1 motif hypermethylation and loss of histone H3 lysine 9 acetylation [O] . Da Li, Fang-Fang Bi, Ji-Min Cao, 2014

机译：调节BRCA1突变的乳腺癌中DNA甲基转移酶1转录的调控：E2F1基序高甲基化与组蛋白H3赖氨酸9乙酰化丧失之间的新型串扰
8. Chromatin Regulation of Estrogen-Mediated Transcription in Breast Cancer: Rules for Binding Sites in Nucleosomes and Modified Histones that Enhance ER Binding [R] . Chrivia, J. C. 2005

机译：染色质调节乳腺癌中雌激素介导的转录：核小体中结合位点的规则和增强ER结合的修饰组蛋白

Regulation of DNA methyltransferase 1 transcription in BRCA1-mutated breast cancer: a novel crosstalk between E2F1 motif hypermethylation and loss of histone H3 lysine 9 acetylation

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