Effects of Enhancer of Zeste Homolog 2 (EZH2) Expression on Brain Glioma Cell Proliferation and Tumorigenesis

机译：Zeste同源2（EZH2）表达增强剂对脑胶质瘤细胞增殖和肿瘤发生的影响

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BackgroundBrain glioma is a type of common primary intracranial malignant tumor, the prognosis of which is frequently unfavorable. Enhancer of zeste homolog 2 (EZH2) belongs to poly-sulfur protein family and can mediate cell proliferation and differentiation via the modulation of various genes expressions. In addition, it is further related with occurrence and metastasis of malignant tumors. This study investigated the effect of EZH2 expression on proliferation and tumorigenesis of brain glioma cells.

机译：背景脑胶质瘤是一种常见的原发性颅内恶性肿瘤，其预后往往不佳。 Zeste同系物2（EZH2）的增强子属于多硫蛋白家族，可以通过调节各种基因表达来介导细胞增殖和分化。另外，它还与恶性肿瘤的发生和转移有关。这项研究调查了EZH2表达对脑胶质瘤细胞增殖和肿瘤发生的影响。

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期刊名称 Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
作者
Tianci Cheng; Yinghui Xu;
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作者单位

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年(卷),期 1923(24),
年度 1923
页码 7249–7255
总页数 7
原文格式 PDF
正文语种
中图分类
关键词
Cell Proliferation, Cells, Glioma;

机译：细胞增殖;细胞;神经胶质瘤;

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专利

1. Inhibition of enhancer of zeste homolog 2 (ezh2) expression is associated with decreased tumor cell proliferation, migration, and invasion in endometrial cancer cell lines [J] . EskanderR.N., JiT., HuynhB., International journal of gynecological cancer: official journal of the International Gynecological Cancer Society . 2013,第6期

机译：Zeste同源物2（ezh2）表达增强子的抑制与子宫内膜癌细胞系中肿瘤细胞增殖，迁移和侵袭减少有关
2. Differential expression of enhancer of zeste homolog 2 (EZH2) protein in small cell and aggressive B-cell non-Hodgkin lymphomas and differential regulation of EZH2 expression by p-ERK1/2 and MYC in aggressive B-cell lymphomas [J] . Xuejun Tian, Ashley Pelton, Ali Shahsafaei, Modern Pathology . 2016,第9期

机译：zeste同源2（EZH2）蛋白增强子在小细胞和侵袭性B细胞非霍奇金淋巴瘤中的差异表达以及p-ERK1 / 2和MYC对侵袭性B细胞淋巴瘤中EZH2表达的差异调节
3. Immunostaining of Increased Expression of Enhancer of Zeste Homolog 2 (EZH2) in Diffuse Midline Glioma H3K27M-Mutant Patients with Poor Survival [J] . Vega Karlowee, Vishwa?Jeet Amatya, Takeshi Takayasu, Pathobiology: journal of immunopathology, molecular and cellular biology . 2019,第2a3期

机译：Zeste Homolog 2（EZH2）增强子表达增加的免疫染色中西脑粘膜H3K27m-突变患者差
4. Up-Regulation of Enhancer of Zeste Homolog 2 Is Associated Positively With Cyclin Dl Overexpression and Poor Clinical Outcome in Head and Neck Squamous Cell Carcinoma [C] . Wei Cao, Zhien Feng, Zhibin Cui, Academic Committee conference of Shanghai key lab of stomatology . 2011

机译：Zeste同源2的增强子的上调与Cyclin Dl过度表达和头颈部鳞状细胞癌的不良临床结果呈正相关。
5. Role of Cell Cycle Regulators Enhancer of Zeste Homolog 2 and Cell Division Cycle 25A in Tumorigenesis of the Aerodigestive Tract [D] . Younis, Rania H. 2011

机译：Zeste同源2和细胞分裂周期25A的细胞周期调节剂增强剂在消化道肿瘤发生中的作用。
6. Inhibition of Enhancer of Zeste Homolog 2 (EZH2) expression is associated with decreased tumor cell proliferation migration and invasion in endometrial cancer cell lines [O] . Ramez N. Eskander, Tao Ji, Be Huynh, -1

机译：Zeste同源2（EZH2）表达增强剂的抑制与子宫内膜癌细胞系中肿瘤细胞增殖迁移和侵袭的减少有关
7. Differential expression of enhancer of zeste homolog 2 (EZH2) protein in small cell and aggressive B-cell non-Hodgkin lymphomas and differential regulation of EZH2 expression by p-ERK1/2 and MYC in aggressive B-cell lymphomas [O] . Xuejun Tian, Ashley Pelton, Ali Shahsafaei, 2016

机译：Zeste同源物2（EZH2）蛋白在小细胞和腐蚀性B细胞非霍奇金淋巴瘤中的差异表达，P-ERK1 / 2和MYC在侵袭性B细胞淋巴瘤中的差异调节

Effects of Enhancer of Zeste Homolog 2 (EZH2) Expression on Brain Glioma Cell Proliferation and Tumorigenesis

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