Diosmetin Attenuates Akt Signaling Pathway by Modulating Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells (NF-κB)/Inducible Nitric Oxide Synthase (iNOS) in Streptozotocin (STZ)-Induced Diabetic Nephropathy Mice

机译：薯met皂素通过调节链脲佐菌素（STZ）诱导的糖尿病性肾病小鼠中活化的B细胞（NF-κB）/诱导型一氧化氮合酶（iNOS）的核因子κ-光链增强剂来减弱Akt信号通路。

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摘要

BackgroundWe evaluated the nephroprotective effect of diosmetin in streptozotocin (STZ)-induced diabetic nephropathy (DN) mice.

机译：背景我们评估了薯os皂素在链脲佐菌素（STZ）诱导的糖尿病肾病（DN）小鼠中的肾保护作用。

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期刊名称 Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
作者
Yingsong Jiang; Jiguo Liu; Zemei Zhou; Ke Liu; Chun Liu;
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作者单位

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年(卷),期 1923(24),
年度 1923
页码 7007–7014
总页数 8
原文格式 PDF
正文语种
中图分类
关键词
Apoptosis, Diabetes Mellitus, Experimental, Diabetic Nephropathies;

机译：细胞凋亡;糖尿病;实验性;糖尿病性肾病;

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专利

1. Liraglutide ameliorates renal injury in streptozotocin-induced diabetic rats by activating endothelial nitric oxide synthase activity via the downregulation of the nuclear factor-kappa B pathway [J] . Zhou Sai-Jun, Bai Lian, Lv Lin, Molecular medicine reports . 2014,第5期

机译：利拉鲁肽通过下调核因子-κB途径激活内皮一氧化氮合酶活性，从而改善链脲佐菌素诱导的糖尿病大鼠的肾脏损伤
2. Manganese induces inducible nitric oxide synthase (iNOS) expression via activation of both MAP kinase and PI3K/Akt pathways in BV2 microglial cells. [J] . Bae JH, Jang BC, Suh SI, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2006,第1a2期

机译：锰通过激活BV2小胶质细胞中的MAP激酶和PI3K / Akt途径，诱导诱导型一氧化氮合酶（iNOS）表达。
3. Tetramethylpyrazine inhibits production of nitric oxide and inducible nitric oxide synthase in lipopolysaccharide-induced N9 microglial cells through blockade of MAPK and PI3K/Akt signaling pathways, and suppression of intracellular reactive oxygen species. [J] . Liu HT, Du YG, He JL, Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs . 2010,第3期

机译：四甲基吡嗪通过阻断MAPK和PI3K / Akt信号通路并抑制细胞内活性氧，抑制脂多糖诱导的N9小胶质细胞中一氧化氮和可诱导型一氧化氮合酶的产生。
4. Minocycline Attenuates Kidney Injury in a Rat Model of Streptozotocin-Induced Diabetic Nephropathy [C] . Hong-ping YUAN, Dong-xu ZHAO, Bo-yin ZHANG International Conference on Biomedical and Biological Engineering . 2016

机译：米诺霉素在链脲佐菌素诱导的糖尿病肾病大鼠模型中衰减肾损伤
5. Central leptin, but not central insulin, attenuates the decrease of adiponectin concentrations and increases insulin sensitivity in streptozotocin (STZ)-induced diabetic rats. [D] . Wang, Jinpin. 2005

机译：在链脲佐菌素（STZ）诱导的糖尿病大鼠中，中央瘦素而非中央胰岛素减弱了脂联素浓度的降低并增加了胰岛素敏感性。
6. Fangchinoline Ameliorates Diabetic Retinopathy by Inhibiting Receptor for Advanced Glycation End-Products (RAGE)-Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells (NF-κB) Pathway in Streptozotocin (STZ)-Induced Diabetic Rats [O] . Qi Wu, Haojie Liu, Ming Zhou 2019

机译：芳基胆碱通过抑制链脲佐菌素（STZ）诱导的糖尿病大鼠中的晚期糖基化终产物（RAGE）-核因子κ-光链-活化的B细胞（NF-κB）途径的受体来减轻糖尿病性视网膜病。
7. Diosmetin Attenuates Akt Signaling Pathway by Modulating Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells (NF-κB)/Inducible Nitric Oxide Synthase (iNOS) in Streptozotocin (STZ)-Induced Diabetic Nephropathy Mice [O] . Yingsong Jiang, Jiguo Liu, Zemei Zhou, 2018

机译：Diosmetin通过调节链脲佐菌素（STZ）诱导的糖尿病肾病小鼠（STZ）诱导的糖尿病肾病小鼠的核因子Kappa-Light-Chop-Enhancer来衰减AKT信号通路。

Diosmetin Attenuates Akt Signaling Pathway by Modulating Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells (NF-κB)/Inducible Nitric Oxide Synthase (iNOS) in Streptozotocin (STZ)-Induced Diabetic Nephropathy Mice

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