Automated synthesis of radiopharmaceuticals for positron emissiontomography: an apparatus for 1-11C labeled carboxylic acid

摘要

A fully automated apparatus for the synthesis and formulation of short-lived ¹¹C (t1/2 = 20 min)-labeled carboxylic acids for positron emission tomograpy (PET) has been developed. Injectable solutions of [1-¹¹C]acetic acid, [1-¹¹C]octanoic acid and [1-¹¹C]palmitic acid wilh radioactivities of 6.36-8.29 GBq, 0.070-1.43 GBq and 0.42-0.89 GBq were obtained. The preparation time was under 40 min after the end of bombardment. An automatic washing function means that labeled compound of the same or different kinds can be produced several times a day without any maintenance of the system. The control system is sited away from the ‘hot laboratory’, so operator exposure to radiation is minimized.