Background. Increased childhood weight gain has been associated with later adiposity. Whether excess early postnatal weight gain plays a role in childhood abdominal fat is unknown. Design. In the ongoing Wheezing Illnesses Study Leidsche Rijn (WHISTLER), birth cohort weight and length from birth to age 3 months were obtained. In the first 316 five-year-olds, intra-abdominal and subcutaneous fat were measured ultrasonographically. Individual weight and length gain rates were assessed in each child. Internal Z-scores of weight for length gain (WLG) were calculated. Multiple imputation was used to deal with missing covariates. Results. Per-1-unit increase in Z-score WLG from birth to 3 months, BMI, waist circumference, and subcutaneous fat were significantly higher; 0.51 kg/m2, 0.84 cm, and 0.50 mm, respectively. After multiple imputation, a trend towards significance was observed for intra-abdominal fat as well (0.51 mm/SD). In the associations with 5-year adiposity, no interaction between postnatal Z-score WLG and birth size was found. Conclusion. Excess early postnatal weight gain is associated with increased general and central adiposity, characterized by more subcutaneous and likely more intra-abdominal fat at 5 years of age.
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机译：背景。儿童体重增加增加与后来的肥胖有关。产后早期体重增加是否过多在儿童腹部脂肪中起作用尚不清楚。设计。在正在进行的喘息性疾病研究Leidsche Rijn（WHISTLER）中，获得了出生队列的重量和从出生到3个月大的长度。在最初的316岁五岁儿童中，超声检查腹部和皮下脂肪。对每个孩子的体重和身高增加率进行了评估。计算了用于长度增加的体重的内部Z分数（WLG）。多重插补用于处理缺失的协变量。结果。从出生到3个月，Z评分WLG每增加1个单位，BMI，腰围和皮下脂肪明显增加；分别为0.51 kg / m 2 ，0.84 cm和0.50 mm。多次插补后，腹内脂肪也观察到显着趋势（0.51 mm / SD）。在伴有5年肥胖的协会中，未发现出生后Z评分WLG与出生体重之间存在相互作用。结论。出生后早期体重增加过多与一般和中枢性肥胖增加有关，其特征是5岁时皮下脂肪增多，腹部脂肪可能增加。
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