Overexpression of serine protease HtrA enhances disruption of adherens junctions paracellular transmigration and type IV secretion of CagA by Helicobacter pylori

摘要

BackgroundThe serine protease HtrA is an important factor for regulating stress responses and protein quality control in bacteria. In recent studies, we have demonstrated that the gastric pathogen Helicobacter pylori can secrete HtrA into the extracellular environment, where it cleaves-off the ectodomain of the tumor suppressor and adherens junction protein E-cadherin on gastric epithelial cells.