Effect of simvastatin on MMPs and TIMPs in cigarette smoke-induced rat COPD model

机译：辛伐他汀对香烟烟雾致大鼠COPD模型中MMP和TIMP的影响

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摘要

BackgroundProteases may play an important role in the development of chronic obstructive pulmonary disease and emphysema in response to cigarette smoke exposure (CSE). The current study was designed to investigate the expression of matrix metalloproteinase (MMP)-8, MMP-9, MMP-12, tissue inhibitor of MMP (TIMP)-1, and TIMP-4 in rat lung tissues in response to CSE, and assessed the effect of simvastatin in regulating expression of MMPs and TIMPs.

机译：背景蛋白酶在响应香烟烟雾暴露（CSE）的慢性阻塞性肺疾病和肺气肿的发生中可能起重要作用。本研究旨在研究CSE对大鼠肺组织中基质金属蛋白酶（MMP）-8，MMP-9，MMP-12，MMP组织抑制剂（TIMP）-1和TIMP-4的表达，以及评估了辛伐他汀在调节MMP和TIMP表达中的作用。

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期刊名称 International Journal of Chronic Obstructive Pulmonary Disease
作者
Jiawei Sun; Jie Bao; Yanan Shi; Bin Zhang; Lindong Yuan; Junhong Li; Lihai Zhang; Mo Sun; Ling Zhang; Wuzhuang Sun;
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作者单位

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年(卷),期 2017(12),-1
年度 2017
页码 717–724
总页数 8
原文格式 PDF
正文语种
中图分类呼吸生理学;
关键词
tissue injury tissue repair smoking;

机译：组织损伤;组织修复;吸烟;

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专利

1. Effect of simvastatin on MMPs and TIMPs in cigarette smoke-induced rat COPD model [J] . Jiawei Sun, Jie Bao, Yanan Shi, International Journal of Chronic Obstructive Pulmonary Disease . 2017,第4期

机译：辛伐他汀对香烟烟雾致大鼠COPD模型中MMP和TIMP的影响
2. Simvastatin mitigates functional and structural impairment of lung and right ventricle in a rat model of cigarette smoke-induced COPD [J] . Yajie Wang, Xue Jiang, Lihai Zhang, International Journal of Clinical and Experimental Pathology . 2014,第12期

机译：辛伐他汀减轻香烟烟雾引起的COPD大鼠模型中肺和右心室的功能和结构损伤
3. Simvastatin mitigates functional and structural impairment of lung and right ventricle in a rat model of cigarette smoke-induced COPD [J] . Yajie Wang, Xue Jiang, Lihai Zhang, International Journal of Clinical and Experimental Pathology . 2014,第12期

机译：辛伐他汀减轻香烟烟雾引起的COPD大鼠模型中肺和右心室的功能和结构损伤
4. Influence of Tonifying Kidney and Spleen, Detoxification of Throat Method to MMP-9, TIMP-1 of IgA Nephropathy Model Rat [C] . Di ZOU, Yin-pin WANG, Tian-ying CHANG, International Conference on Biomedical and Biological Engineering . 2016

机译：调整肾脏和脾，咽喉溶解对IGA肾病模型大鼠MMP-9的影响
5. In vivo and in vitro models for cigarette smoke-induced low birth weight and other adverse developmental outcomes [D] . Esposito, Emily Roberts 2008

机译：香烟引起的低出生体重和其他不良发育结果的体内和体外模型
6. Simvastatin mitigates functional and structural impairment of lung and right ventricle in a rat model of cigarette smoke-induced COPD [O] . Yajie Wang, Xue Jiang, Lihai Zhang, 2014

机译：辛伐他汀减轻香烟烟雾引起的COPD大鼠模型中肺和右心室的功能和结构损伤
7. Effect of simvastatin on MMPs and TIMPs in cigarette smoke-induced rat COPD model [O] . Jiawei Sun, Jie Bao, Yanan Shi, 2017

机译：Simvastatin对卷烟烟雾诱导大鼠COPD模型中MMPS和TIMPS的影响

Effect of simvastatin on MMPs and TIMPs in cigarette smoke-induced rat COPD model

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