Purpose Intravenous methylprednisolone (IVMP) pulse therapy is the first-line treatment in active moderate-to-severe Graves' orbitopathy (GO) and dysthyroid optic neuropathy (DON). One of the adverse effects of this therapy is liver dysfunction that can be mild (ALT < 100 U/L), moderate (ALT: 100–300 U/L), and severe defined as acute liver injury (ALI) (ALT > 300 U/L). ALI can be irreversible and fatal. The aim of the study was to evaluate the influence of two different schemes of therapy with IVMP in moderate-to-severe GO and DON on biochemical liver parameters.
展开▼
机译：目的静脉注射甲基强的松龙（IVMP）脉冲疗法是活动性中度至重度Graves眼病（GO）和甲状腺功能失调性视神经病变（DON）的一线治疗。该疗法的不良反应之一是轻度（ALT <100 U / L），中度（ALT：100–300 U / L）和严重的急性肝损伤（ALI）（ALT> 300） U / L）。 ALI可能是不可逆的并且致命的。这项研究的目的是评估在中重度GO和DON中使用IVMP的两种不同治疗方案对生化肝参数的影响。
展开▼
