Mechano-signalling induced by fullerene C60 nanofilms arrests the cell cycle in the G2/M phase and decreases proliferation of liver cancer cells

摘要

Introduction and objectiveDegradation of the extracellular matrix (ECM) changes the physicochemical properties and dysregulates ECM–cell interactions, leading to several pathological conditions, such as invasive cancer. Carbon nanofilm, as a biocompatible and easy to functionalize material, could be used to mimic ECM structures, changing cancer cell behavior to perform like normal cells.