Positively charged cholesterol–recombinant human gelatins foster the cellular uptake of proteins and murine immune reactions

摘要

PurposeRecombinant human gelatins with defined molecular weights were modified with cholesterol to make them amphiphilic in nature. We investigated the feasibility of these modified human gelatins acting as a carrier of antigenic proteins for inducing cellular immunity. The aim of this study was to synthesize novel and effective compounds for vaccine delivery in vivo.