In Vitro Differentiation and Expansion of Intrathymic T Cell Progenitors from Human Umbilical Cord Blood-Derived CD34+ Cells

摘要

Background and Objectives:CD4 positive cells play a central role in many lethal diseases, such as AIDS, cancer and autoimmunity diseases. CD4⁻ commitment of hematopoietic stem cells involved in T cell lineage, monocyte and dendritic cells development. In this study, we showed that CD4 commitment out of thymus which may happen when hematopoietic cells undergo monocyte, dendritic cells or even earlier T cell progenitor differentiation.