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Effects of Combination Treatment of Alpha 1-Adrenergic Receptor Antagonists on Voiding Dysfunction: Study on Target Organs in Overactive Bladder Rats

机译：α1-肾上腺素能受体拮抗剂联合治疗对空泡功能障碍的影响：膀胱过度活动症大鼠靶器官的研究

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摘要

PurposeOveractive bladder (OAB) causes urinary urgency, usually accompanied by frequency and nocturia. Alpha 1-adrenergic receptor (α1-AR) antagonists are known to improve lower urinary tract symptoms associated with OAB. The α1-AR antagonists constitute a variety of drugs according to the receptor subtype affinity. This study investigated the efficacy of tamsulosin, naftopidil, and a combination of the two on OAB rats.

机译：目的膀胱过度活动症（OAB）引起尿急，通常伴有尿频和夜尿症。已知α1-肾上腺素能受体（α1-AR）拮抗剂可改善与OAB相关的下尿路症状。根据受体亚型亲和力，α1-AR拮抗剂可构成多种药物。这项研究调查了坦索罗辛，那夫多地尔和两者的组合对OAB大鼠的疗效。

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期刊名称 International Neurourology Journal
作者
Il Gyu Ko; Bo Min Moon; Sung Eun Kim; Jun Jang Jin; Lakkyong Hwang; Eun Sang Ji; Chang Ju Kim; Tai Hyung Kim; Hyun Hee Choi; Kyung Jin Chung;
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作者单位

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年(卷),期 2016(20),Suppl 2
年度 2016
页码 S150–158
总页数 9
原文格式 PDF
正文语种
中图分类神经科学;
关键词
Urinary Bladder Overactive; Tamsulosin; Naftopidil; c-Fos; Nerve Growth Factor;

机译：膀胱膀胱过度活动症;坦索罗辛;萘甲地尔;c-Fos;神经生长因子;

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专利

1. Effects of Combination Treatment of Alpha 1-Adrenergic Receptor Antagonists on Voiding Dysfunction: Study on Target Organs in Overactive Bladder Rats [J] . International Neurourology Journal . 2016,第Suppla2期

机译：α1-肾上腺素能受体拮抗剂联合治疗对排尿功能障碍的影响：膀胱过度活动症大鼠靶器官的研究
2. Effects of alpha 1-adrenergic receptor subtype selective antagonists on lower urinary tract function in rats with bladder outlet obstruction. [J] . Gu B, Reiter JP, Schwinn DA, The Journal of Urology . 2004,第2期

机译：α1-肾上腺素能受体亚型选择性拮抗剂对膀胱出口梗阻大鼠下尿路功能的影响。
3. Expression of E-series prostaglandin (EP) receptors and urodynamic effects of an EP₄ receptor antagonist on cyclophosphamide-induced overactive bladder in rats [J] . Yao-Chi Chuang, Naoki Yoshimura, Chao-Cheng Huang, BJU International . 2010,第11期

机译：E系列前列腺素（EP）受体的表达和EP _{4 受体拮抗剂对大鼠环磷酰胺诱导的膀胱过度活动症的尿动力学影响}
4. Electrical Stimulation of the Transcutaneous Posterior Tibial Nerve for the Treatment of Patients with Detrusor Overactivity Due to Neurogenic Hiperactive Bladder in Multiple Sclerosis A Case Study [C] . Fabiana S. B. Perez, Luciana R. Tenorio Peixoto, Fabiano Soares, International Conference on Biomedical Electronics and Devices . 2014

机译：经皮后胫骨神经的电气刺激治疗多发性硬化中神经源性膀胱患者患者的患者案例研究
5. K+ Channels and Beta3 adrenergic receptors as new pharmacological targets for overactive bladder treatment. [D] . Afeli, Serge Amani Yao. 2013

机译：K +通道和Beta3肾上腺素能受体是膀胱过度活跃症治疗的新药理靶标。
6. Combination phosphodiesterase type 4 inhibitor and phosphodiesterase type 5 inhibitor treatment reduces non-voiding contraction in a rat model of overactive bladder [O] . Brian M. Balog, Abhilasha Tangada, Pooja Sheth, 2012

机译：磷酸二酯酶4型抑制剂和磷酸二酯酶5型抑制剂的组合治疗可减轻膀胱过度活动症大鼠模型中的非空洞收缩
7. Effects of Combination Treatment of Alpha 1-Adrenergic Receptor Antagonists on Voiding Dysfunction: Study on Target Organs in Overactive Bladder Rats [O] . Il Gyu Ko, Bo Min Moon, Sung Eun Kim, 2016

机译：α1-肾上腺素能受体拮抗剂组合治疗对多功能血管大鼠靶器官研究的影响

Effects of Combination Treatment of Alpha 1-Adrenergic Receptor Antagonists on Voiding Dysfunction: Study on Target Organs in Overactive Bladder Rats

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