首页> 美国卫生研究院文献>Iranian Journal of Psychiatry >Evaluation of Cerebral Cortex Function in Clients with Bipolar Mood Disorder I (BMD I) Compared With BMD II Using QEEG Analysis
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Evaluation of Cerebral Cortex Function in Clients with Bipolar Mood Disorder I (BMD I) Compared With BMD II Using QEEG Analysis

机译:使用QEEG分析评估双相情感障碍I(BMD I)与BMD II相比较的客户的大脑皮质功能

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摘要

>Objective: Early diagnosis of type I and type II bipolar mood disorder is very challenging particularly in adolescence. Hence, we aimed to investigate the cerebral cortex function in these patients, using quantitative electroencephalography analysis to obtain significant differences between them. >Methods: Thirty- eight adolescents (18 patients with bipolar disorder I and 20 with BMD II) participated in this study. We recorded the electroencephalogram signals based on 10-20 international system by 21 electrodes in eyes open and eyes closed condition resting conditions. Forty seconds segments were selected from each recorded signals with minimal noise and artifacts. Periodogram Welch was used to estimate power spectrum density from each segment. Analysis was performed in five frequency bands (delta, theta, alpha, beta and gamma), and we assessed power, mean, entropy, variance and skewness of the spectrums, as well as mean of the thresholded spectrum and thresholded spectrogram. We only used focal montage for comparison. Eventually, data were analyzed by independent Mann-Whitney test and independent t test. >Results: We observed significant differences in some brain regions and in all frequency bands. There were significant differences in prefrontal lobe, central lobe, left parietal lobe, occipital lobe and temporal lobe between BMD I and BMD II (P < 0.05). In patients with BMD I, spectral entropy was compared to patients with BMD II. The most significant difference was observed in the gamma frequency band. Also, the power and entropy of delta frequency band was larger in the left parietal lobe in the BMD I patients compared to BMD II patients (P < 0.05). In the temporal lobe, significant differences were observed in the spectrum distribution of beta and gamma frequency bands (P < 0.05). >Conclusion: The QEEG and entropy measure are simple and available tools to help detect cerebral cortex deficits and distinguish BMD I from BMD II.
机译:>目的:尤其是在青春期中,I型和II型双相情感障碍的早期诊断非常具有挑战性。因此,我们旨在调查这些患者的大脑皮质功能,使用定量脑电图分析来获得他们之间的显着差异。 >方法:本研究共纳入38名青少年(18例双相情感障碍I患者和20例BMD II患者)。我们记录了基于10-20国际系统的21个电极在睁眼和闭眼休息状态下的脑电图信号。从每个记录的信号中选择了40秒的片段,并且噪声和伪像最少。周期图韦尔奇用于估计每个段的功率谱密度。在五个频带(δ,θ,α,β和γ)中进行了分析,我们评估了频谱的功率,均值,熵,方差和偏度,以及阈值频谱和阈值频谱图的平均值。我们仅使用聚焦蒙太奇进行比较。最终,通过独立的Mann-Whitney检验和独立的t检验分析数据。 >结果:我们观察到某些大脑区域和所有频段存在显着差异。 BMD I和BMD II之间的前额叶,中央叶,左顶叶,枕叶和颞叶存在显着差异(P <0.05)。在BMD I患者中,光谱熵与BMD II患者进行了比较。在伽玛频段上观察到最明显的差异。同样,与BMD II患者相比,BMD I患者的左顶叶三角洲频带的功率和熵更大(P <0.05)。在颞叶,β和γ频段的频谱分布存在显着差异(P <0.05)。 >结论:QEEG和熵测度是简单易用的工具,可帮助检测大脑皮质缺陷并区分BMD I和BMD II。

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