Effectivity of One Session Charcoal Hemoperfusion Treatment in Severe Carbamazepine Poisoning

摘要

A carbamazepine intoxication with suicide attempt is a relatively common clinical problem that presenting with coma, respiratory depression, arrhythmia, hemodynamic instability and even death. We report a case of severe carbamazepine poisoning that was successfully treated with one session charcoal hemoperfusion. On admission, the patient was comatose and required ventilator support. Hemoperfusion with coated activated charcoal successfully decreased the serum carbamazepine concentration from 45 µg mL⁻¹ to 21 µg mL⁻¹ within 2 h, with subsequent clinical improvement.