Phakellistatins: An Underwater Unsolved Puzzle

摘要

A critical summary on the discovery of the nineteen members of the phakellistatin family (phakellistatin >1–>19), cytotoxic proline-rich cyclopeptides of marine origin, is reported. Isolation, structural elucidation, and biological properties of the various-sized natural macrocycles are described, along with the total syntheses and the enigmatic issues of the cytotoxic activity reproducibility.