Isolation and Assessment of the in Vitro Anti-Tumor Activity of Smenothiazole A and B Chlorinated Thiazole-Containing Peptide/Polyketides from the Caribbean Sponge Smenospongia aurea

摘要

The study of the secondary metabolites contained in the organic extract of Caribbean sponge Smenospongia aurea led to the isolation of smenothiazole A (>3) and B (>4), hybrid peptide/polyketide compounds. Assays performed using four solid tumor cell lines showed that smenothiazoles exert a potent cytotoxic activity at nanomolar levels, with selectivity over ovarian cancer cells and a pro-apoptotic mechanism.