Secondary Metabolites from Penicillium pinophilum SD-272 a Marine Sediment-Derived Fungus

摘要

Two new secondary metabolites, namely, pinodiketopiperazine A (>1) and 6,7-dihydroxy-3-methoxy-3-methylphthalide (>2), along with alternariol 2,4-dimethyl ether (>3) and l-5-oxoproline methyl ester (>4), which were isolated from a natural source for the first time but have been previously synthesized, were characterized from the marine sediment-derived fungus Penicillium pinophilum SD-272. In addition, six known metabolites (>5–>10) were also identified. Their structures were elucidated by analysis of the NMR and mass spectroscopic data. The absolute configuration of compound >1 was determined by experimental and calculated ECD spectra. Compound >2 displayed potent brine shrimp (Artemia salina) lethality with LD50 11.2 μM.