Delayed Motherhood Increases the Probability of Sons to be Infertile

摘要

>Purpose: To ascertain whether advanced maternal age at birth is associated with offspring infertility.>Methods: A written questionnaire was completed by infertile couples attending our clinic in the presence of a researcher.>Results: Maternal age at birth (odds ratio 1.236, 95% CI 1.100–1.388) and birth order of all respondents and their respective siblings (odds ratio 0.551, 95% CI 0.351–0.865) were significant predictors of male infertility. The probability of a man being infertile increased as mother's age at birth increased (regression coefficient ± standard error 0.212 ± 0.059; P < 0.001), but decreased as birth order increased (regression coefficient ± standard error −0.596 ± 0.230; P = 0.010).>Conclusions: Delayed motherhood may enhance the probability of sons to be infertile. The probability of a man being infertile would be greater if he comes from a small family than if he comes from a large family.