Label-free electrochemical sensor to investigate the effect of tocopherol on generation of superoxide ions following UV irradiation

摘要

BackgroundGeneration of reactive oxygen species (ROS), triggered by ultraviolet radiation (UVR), is associated with carcinogenesis of the skin. UV irradiation induced superoxide anion (O2^•−) is the key ROS involved in the cellular damage. The cytoprotective efficacy of an unknown anti-oxidant compound can be evaluated by analyzing the production of O2^•− from treated cells.