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RELATION OF PYROGENIC AND EMETIC PROPERTIES OF ENTEROBACTERIACEAL ENDOTOXIN AND OF STAPHYLOCOCCAL ENTEROTOXIN

机译:肠细菌内毒素和葡萄球菌肠毒素的产热和呕吐性质的关系

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摘要

Martin, William J. (College of Medicine, University of Utah, Salt Lake City), and Stanley Marcus. Relation of pyrogenic and emetic properties of enterobacteriaceal endotoxin and of staphylococcal enterotoxin. J. Bacteriol. >87:1019–1026. 1964.—The pyrogenic, endotoxic fraction of enterobacteriaceal organisms, isolated in a relatively impure or purified state, is both pyrogenic in rabbits and cats as well as emeticogenic in cats in microgram amounts. Employing classical methods for preparation of enterobacteriaceal endotoxin from known enterotoxic strains of Staphylococcus aureus yielded preparations with less than one-hundredth the activity of the enterobacteriaceal material. However, a purified enterotoxin material from an S. aureus strain, with protein-like rather than polysaccharidelike properties, was found to be both pyrogenic and emeticogenic in microgram amounts. These results suggest the probability that the enterobacteriaceal pyrogenemetic substance(s) is a significant part of the whole cell, whereas the staphylococcal enterotoxin is elaborated as a metabolic product which apparently does not accumulate in the whole cell.
机译:Martin,William J.(犹他大学,盐湖城大学医学院)和Stanley Marcus。肠杆菌内毒素和葡萄球菌肠毒素的热原和催吐特性的关系。 J.细菌。 > 87: 1019-1026。 1964年。以相对不纯或纯净的状态分离出的肠杆菌科细菌的热原性,内毒素级成分,在兔子和猫中均具有热原性,在猫中也具有微克量的催吐性。采用经典方法从已知的金黄色葡萄球菌肠毒性菌株中制备肠杆菌内毒素,所制备的制剂的肠杆菌活性低于其百分之一。然而,发现具有金黄色葡萄球菌菌株的纯化的肠毒素材料具有蛋白质样而不是多糖样的性质,其以微克量为热原和催吐的。这些结果表明,肠细菌热解物质是整个细胞的重要组成部分,而葡萄球菌肠毒素是作为代谢产物而精心设计的,而该代谢产物显然不会在整个细胞中蓄积。

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