BCl3-Mediated C–N C–Sand C–O Bond Formation of Imidazo12-apyridine Benzylic Ethers

摘要

An efficient BCl3-mediated reaction of imidazo[1,2-a]pyridines has been developed for the C–N, C–S, and C–O bond formation. The salient features of this method correspond to the substitution of different nucleophiles via in situ unconventional debenzylation. The developed process is applicable for the synthesis of a wide variety of ((3-amino/thio/alkoxy)-methyl)-imidazo[1,2-a]pyridines.