A290 THE ATF6 ARM OF ER STRESS ANTAGONIZES METABOLIC STRESS-INDUCED DECREASES IN EPITHELIAL BARRIER FUNCTION TO COMMENSAL BACTERIA BY PROMOTING XENOPHAGY

摘要

BackgroundThe barrier function of the intestinal epithelium is a first-line of defense that is compromised in IBD. We have shown that epithelia treated with dinitrophenol (DNP: uncouples oxidative phosphorylation) have a dramatic impairment in their barrier function, and internalize non-invasive commensal E. coli. Mitochondria do not function in isolation; they are closely aligned with the endoplasmic reticulum (ER).