A164 RAPID INTRAHEPATIC AND PERIPHERAL BLOOD HCV RNA DECLINE AND HCV-SPECIFIC IMMUNE RESPONSE INCREASE DURING IFN-FREE DAA THERAPY IN HCV TREATMENT-NAÏVE PATIENTS

机译：A164在无初治者接受HCV治疗期间肝内和外周血HCV RNA快速下降和HCV特异性免疫应答增加

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BackgroundInterferon (IFN)-free HCV direct-acting antiviral (DAA) treatment regimens lead to rapid HCV RNA decline and high rates of sustained virologic response (SVR).

机译：背景不含干扰素（IFN）的HCV直接作用抗病毒（DAA）治疗方案导致HCV RNA快速下降和持续病毒学应答（SVR）的发生率很高。

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期刊名称 Journal of the Canadian Association of Gastroenterology
作者
S A MacParland; V Cherepanov; L Vijgen; M Gamil; M Beumont; S Yoon; A Rahman; C Capraru; M A Ostrowski; M Brahmania; D Wong; R Harrigan; H L Janssen; M S Sulkowski; J Feld;
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年(卷),期 2018(1),Suppl 1
年度 2018
页码 284–285
总页数 2
原文格式 PDF
正文语种
中图分类肠道病毒与肝炎病毒;肝及胆疾病;肠疾病;
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专利

1. Rapid intrahepatic and peripheral blood HCV RNA decline and HCV-specific immune response increase during IFN-free DAA therapy in HCV treatment-naive patients [J] . MacParland Sonya A., Cherepanov Vera, Vijgen Leen, Hepatology: Official Journal of the American Association for the Study of Liver Diseases . 2016,第S1期

机译：快速肝内和外周血HCV RNA下降和HCV特异性免疫反应在HCV治疗 - 天真患者中的IFN DAA治疗期间增加
2. IFN-free DAA therapy does not fully re-constitute the altered phenotype and function of HCV-specific CD8+T cells but immune checkpoint inhibitions can selectively re-invigorate the functionality during chronic HCV. [J] . Aregay Amare, Deterding Katja, Manns Michael P., Hepatology: Official Journal of the American Association for the Study of Liver Diseases . 2017,第Suppla1期

机译：自由IFN的DAA治疗不完全重新构成HCV特异性CD8 + T细胞的改变的表型和功能，但免疫检查点抑制可以在慢性HCV期间选择性地重新振动功能。
3. HCV RNA in peripheral blood mononuclear cells may predict sustained virological response to DAAs therapy in HCV patients [J] . Chi Xiumei, Wu Rui, Wang Xiaomei, Hepatology: Official Journal of the American Association for the Study of Liver Diseases . 2017,第Suppla1期

机译：外周血单核细胞中的HCV RNA可以预测HCV患者的DAAS治疗的持续病毒学应答
4. IDENTIFICATION OF GENES RELATED TO IN HUMAN PERIPHERAL BLOOD MONONUCLEAR CELL (PBMC) OF PATIENTS WITH HCV BY mRNA DIFFERENTIAL DISPLAY METHOD [C] . Xufang Hu, Xiaozhao Deng, Zhenyu Diao, 第四届国际后基因组生命科学技术学术论坛 . 2006

机译：mRNA差异显示法鉴定丙型肝炎患者外周血单核细胞（PBMC）相关基因。
5. The Distribution of Change over Time in Metabolic, Inflammatory, and Immune Parameters in HCV-monoinfected and HIV/HCV-coinfected Patients Cured of Hepatitis C Virus by Direct-Acting Antiviral Therapy [D] . Emmanuel, Benjamin. 2018

机译：通过直接作用抗病毒治疗，在HCV-单染料和HCV / HCV / HCV-焦收的患者中的代谢，炎症和免疫参数随时间随时间的分布，通过直接作用抗病毒治疗治愈丙型肝炎病毒
6. Rapid reversal of innate immune dysregulation in blood of patients and livers of humanized mice with HCV following DAA therapy [O] . Matthew A. Burchill, Justin A. Roby, Nanette Crochet, -1

机译：DAA治疗后人源化HCV小鼠的患者和肝脏血液中天然免疫异常迅速逆转
7. Rapid reversal of innate immune dysregulation in blood of patients and livers of humanized mice with HCV following DAA therapy. [O] . Matthew A Burchill, Justin A Roby, Nanette Crochet, 2017

机译：在Daa治疗后患有HCV的人源化小鼠的肝脏中的先天免疫失调的快速逆转。

A164 RAPID INTRAHEPATIC AND PERIPHERAL BLOOD HCV RNA DECLINE AND HCV-SPECIFIC IMMUNE RESPONSE INCREASE DURING IFN-FREE DAA THERAPY IN HCV TREATMENT-NAÏVE PATIENTS

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