A14 INFLAMMASOME ACTIVATION COORDINATES INTESTINAL MUCOSAL DEFENSE AGAINST THE ENTERIC BACTERIAL PATHOGEN SALMONELLA ENTERICASEROVAR TYPHIMURIUM.

摘要

BackgroundIntestinal epithelial cells (IECs) play a central role in the coordination of intestinal homeostasis. They must strike a careful balance to temper pro-inflammatory responses against the intestinal microbiota, while remaining vigilant and rapidly responsive when exposed to a noxious stimulus such as an enteric pathogen. One early response mechanism by which IECs engage in immune defense is through the activation of an IEC-specific inflammasome. This activation triggers the extrusion of infected IEC into the gut lumen, ultimately restricting Salmonella enterica serovar Typhimurium from escaping the gut and spreading systemically. However, it appears the role of the inflammasome in gut defense is not just restricted to IEC shedding but it also plays a key role in mucin secretion and antimicrobial lectin production.