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Mucosal defense and maturation of intestinal/lung function in preterm infants

机译:早产儿的黏膜防御和肠/肺功能的成熟

摘要

The present invention is selected from the group consisting of α-defensin, β-defensin, cathelicidin, lactoferrin/lactofericin and lysozyme and/or GLP-2 or GLP-2 analogs in premature infants, or in mothers due to preterm birth. A method of preventing cytokine storms by maturing mucosal defenses and rebalancing the immune system, comprising administering at least one antimicrobial peptide orally and/or intrapulmonally and/or subcutaneously; It relates to a method for the treatment or prevention of neonatal sepsis, necrotizing enteritis, acute and long-term diarrhea, short bowel syndrome, respiratory diseases, respiratory infections, respiratory failure, neurodevelopmental injury and ectopic growth restriction.
机译:本发明选自早产儿或早产母亲中的α-防御素,β-防御素,cathelicidin,乳铁蛋白/乳铁蛋白和溶菌酶和/或GLP-2或GLP-2类似物。一种通过使粘膜防御层成熟并使免疫系统平衡来预防细胞因子风暴的方法,该方法包括口服和/或经皮内和/或皮下给予至少一种抗菌肽。本发明涉及治疗或预防新生儿败血症,坏死性肠炎,急性和长期腹泻,短肠综合征,呼吸系统疾病,呼吸道感染,呼吸衰竭,神经发育损伤和异位生长受限的方法。

著录项

  • 公开/公告号KR20200095472A

    专利类型

  • 公开/公告日2020-08-10

    原文格式PDF

  • 申请/专利权人 디펜신 테라퓨틱스 에이피에스;

    申请/专利号KR20207015411

  • 发明设计人 노드킬드 피터;

    申请日2018-11-09

  • 分类号A61K38/17;A61K47/64;A61P1;A61P1/12;A61P11;C07K14/47;

  • 国家 KR

  • 入库时间 2022-08-21 11:06:13

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