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Multikinase inhibitor sorafenib prevents pressure overload-induced left ventricular hypertrophy in rats by blocking the c-Raf/ERK1/2 signaling pathway

机译：多激酶抑制剂索拉非尼通过阻断c-Raf / ERK1 / 2信号通路来预防压力超负荷引起的大鼠左室肥大

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BackgroundLeft ventricular hypertrophy (LVH) is a potent risk factor for sudden death and congestive heart failure.

机译：背景左室肥厚（LVH）是猝死和充血性心力衰竭的潜在危险因素。

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期刊名称 Journal of Cardiothoracic Surgery
作者
Arezoo Daryadel; Anna Bogdanova; Max Gassmann; Xavier Mueller; Gregor Zünd; Burkhardt Seifert; Christine Lehalle; Nelly Frossard; Reza Tavakoli;
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作者单位

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年(卷),期 2014(9),-1
年度 2014
页码 81
总页数 9
原文格式 PDF
正文语种
中图分类心血管疾病;
关键词
Left ventricular hypertrophy Sorafenib c-Raf ERK1/2;

机译：左心室肥大;索拉非尼;c-Raf;ERK1 / 2;

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专利

1. Multikinase inhibitor sorafenib prevents pressure overload-induced left ventricular hypertrophy in rats by blocking the c-Raf/ERK1/2 signaling pathway [J] . Arezoo Daryadel, Anna Bogdanova, Max Gassmann, Journal of Cardiothoracic Surgery . 2014,第1期

机译：多激酶抑制剂索拉非尼通过阻断c-Raf / ERK1 / 2信号通路来预防压力超负荷引起的大鼠左室肥大
2. Rosuvastatin prevents pressure overload-induced myocardial hypertrophy via inactivation of the Akt, ERK1/2 and GATA4 signaling pathways in rats [J] . XuX., ZhangL., LiangJ. Molecular medicine reports . 2013,第2期

机译：瑞舒伐他汀通过使大鼠Akt，ERK1 / 2和GATA4信号通路失活来预防压力超负荷引起的心肌肥大
3. Myofilament Ca2+ sensitivity correlates with left ventricular contractility during the progression of pressure overload-induced left ventricular myocardial hypertrophy in rats [J] . Ruppert Mihaly, Bodi Beata, Korkmaz-Icoez Sevil, Journal of Molecular and Cellular Cardiology . 2019,第期

机译：肌丝CA2 +敏感性与左心室收缩性在大鼠中的压力进展过程中与左心室收缩性相关联
4. AcSDKP inhibits the proliferation and collagen expression of cardiac fibroblasts induced by PDGF through blocking the ERK1/2 and JNK pathway activation [C] . Zhang Lijuan, Yang Fang, Li Qian, 2011 International Conference on Human Health and Biomedical Engineering . 2011

机译：AcSDKP通过阻断ERK1 / 2和JNK途径的激活来抑制PDGF诱导的心脏成纤维细胞的增殖和胶原蛋白表达
5. Modeling and Measurement of Pressure Overload-Induced Changes in Left Ventricular Structure and Function [D] . Farrar, Genevieve E. 2014

机译：压力超负荷导致左心室结构和功能变化的建模和测量
6. Cardiac-restricted overexpression or deletion of tissue inhibitor of matrix metalloproteinase-4: differential effects on left ventricular structure and function following pressure overload-induced hypertrophy [O] . William M. Yarbrough, Catalin Baicu, Rupak Mukherjee, -1

机译：心脏受限的基质金属蛋白酶4的组织抑制剂的过表达或缺失：压力超负荷引起的肥大后对左心室结构和功能的差异作用
7. Multikinase inhibitor sorafenib prevents pressure overload-induced left ventricular hypertrophy in rats by blocking the c-Raf/ERK1/2 signaling pathway [O] . Arezoo Daryadel, Anna Bogdanova, Max Gassmann, 2014

机译：多激酶抑制剂索拉非尼通过阻断c-Raf / ERK1 / 2信号通路来预防压力超负荷引起的大鼠左室肥大

Multikinase inhibitor sorafenib prevents pressure overload-induced left ventricular hypertrophy in rats by blocking the c-Raf/ERK1/2 signaling pathway

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