In regard to The Italian Association of Radiotherapy and Oncology Recommendation for Breast Tumor Recurrence: Grades of Recommendation Assessment Development and Evaluation Criteria

摘要

We congratulate Bottero et al. [1] on the publication of the Italian Association of Radiotherapy and Clinical Oncology recommendations in cases of ipsilateral breast tumor recurrence. The aim of this review was to compare oncological outcomes after a second conservative treatment (2nd CT) based on lumpectomy plus re-irradiation of the tumor bed vs. salvage mastectomy (SM), which has been considered a priority clinical question by the authors. As mentioned by the panel, currently there is no phase III prospective randomized trial comparing these tow salvage treatment options. The results reported by the authors give rise to four important remarks.