Spermatozoa Induce Maternal Mononuclear Cells for Productionof Antibody with Cytotoxic Activity on PaternalBlood Mononuclear Cells

摘要

The maternal immune response to paternal antigens is induced at insemination. We believe that pregnancy protectivealloantibodies, such as anti-paternal cytotoxic antibody (APCA), may be produced against the paternal antigens in the contextof stimulated immunity at insemination and that they increase during pregnancy. APCA is necessary for pregnancy. It is directedtowards paternal human leucocyte antigens (HLAs) and has cytotoxic activity against paternal leucocytes. The present studyaims to determine whether APCA is produced by the maternal peripheral blood mononuclear cells (PBMCs) in contact with thehusband’s spermatozoa and to evaluate the relation of APCA production with HLA class I and II expressions by spermatozoa infertile couples.