首页> 美国卫生研究院文献>AJNR: American Journal of Neuroradiology >Characterization of Cyclic CSF Flow in the Foramen Magnum and Upper Cervical Spinal Canal with MR Flow Imaging and Computational Fluid Dynamics
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Characterization of Cyclic CSF Flow in the Foramen Magnum and Upper Cervical Spinal Canal with MR Flow Imaging and Computational Fluid Dynamics

机译:具有MR流成像和计算流体动力学的植物鳞片和上部颈椎管中循环CSF流动的表征

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摘要

CSF flow has been shown to exhibit complex patterns in MR images in both healthy subjects and in patients with Chiari I. Abnormal CSF flow oscillations, according to prevailing opinion, cause syringomyelia and other clinical manifestations that affect some patients with the Chiari I malformation. For this article, we reviewed the literature on PC MR of CSF flow, collected the published CFD studies relevant to CSF flow, and performed flow simulations. PC MR creates cine and still images of CSF flow and measurements of flow velocities. CFD, a technique used to compute flow and pressure in liquid systems, simulates the CSF flow patterns that occur in a specific geometry or anatomy of the SAS and a specific volume of flow. Published PC MR studies show greater peak CSF velocities and more complex flow patterns in patients with Chiari I than in healthy subjects, with synchronous bidirectional flow one of the characteristic markers of pathologic flow. In mathematic models of the SAS created from high-resolution MR images, CFD displays complex CSF flow patterns similar to those shown in PC MR in patients. CFD shows that the pressure and flow patterns vary from level to level in the upper spinal canal and differ between patients with Chiari and healthy volunteers. In models in which elasticity and motion are incorporated, CFD displays CSF pressure waves in the SAS. PC MR and CFD studies to date demonstrate significant alterations of CSF flow and pressure patterns in patients with Chiari I. CSF flow has nonlaminar complex spatial and temporal variations and associated pressure waves and pressure gradients. Additional simulations of CSF flow supplemented by PC MR will lead to better measures for distinguishing pathologic flow abnormalities that cause syringomyelia, headaches, and other clinical manifestations in Chiari I malformations.
机译:已经显示CSF流程,在健康受试者和Chiari I.患者中表现出在HER图像中表现出复杂的图案。根据普遍的意见,导致切割症和其他影响一些患者的临床表现,对CHIARI I畸形的其他临床表现。对于本文,我们审查了CSF流程MR的文献,收集了与CSF流程相关的已发表的CFD研究,并进行了流量模拟。 PC MR创建CINE和静止图像的CSF流量和流速测量。 CFD,用于计算液体系统中的流量和压力的技术,模拟在特定几何形状或SA的解剖结构中发生的CSF流动模式和特定的流量。已发布的PC先生研究表明,Chiari I的患者中的峰值CSF速度和更复杂的流动模式,而不是在健康受试者中,具有同步双向流量的病理流程的特征标记之一。在从高分辨率MR图像创建的SA的数学模型中,CFD显示与患者PC MR中所示的复杂CSF流模式。 CFD表明,压力和流动模式从上脊柱管道中的水平变化,患有Chiari和健康志愿者的患者之间的差异。在包含弹性和运动的模型中,CFD在SA中显示CSF压力波。迄今为止,PC先生和CFD研究表明,CSF流动患者的CSF流量和压力模式的显着改变,CSF流量具有非基本的复杂空间和时间变化和相关的压力波和压力梯度。 PC MR补充的CSF流量的额外模拟将导致在Chiari I畸形中区分导致掺入的病理流动异常,令人生畏的病理流动异常。

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