Apparent Diffusion Coefficient Reveals Gray and White Matter Disease and T2 Mapping Detects White Matter Disease in the Brain in Feline Alpha-Mannosidosis

摘要

BACKGROUND AND PURPOSE: Methods to locate and identify brain pathology are critical for monitoring disease progression and for evaluating the efficacy of therapeutic intervention. The purpose of this study was to detect cell swelling, abnormal myelin, and astrogliosis in the feline model of the lysosomal storage disease α-mannosidosis (AMD) by using diffusion and T2 mapping.