Genotype Phenotype Correlation of Genetic Polymorphism of PPAR Gamma Gene and Therapeutic Response to Pioglitazone in Type 2 Diabetes Mellitus- A Pilot Study

机译：2型糖尿病患者PPARγ基因遗传多态性的基因型表型相关性与对吡格列酮的治疗反应

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IntroductionPro12Ala polymorphism is a missense mutation at codon 12 in peroxisome proliferator-activated receptor γ gene (PPARG). This polymorphism is known to be associated with increased insulin sensitivity. Pioglitazone, a thiazolidinedione, is an anti-diabetic drug which acts as an agonist at PPAR γ receptor.

机译：简介Pro12Ala多态性是过氧化物酶体增殖物激活受体γ基因（PPARG）中第12位密码子的错义突变。已知该多态性与胰岛素敏感性增加有关。吡格列酮，噻唑烷二酮，是一种抗糖尿病药物，在PPARγ受体上起激动剂的作用。

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期刊名称 Journal of Clinical and Diagnostic Research : JCDR
作者
S. Shanmuga Priya; Ramalingam Sankaran; Sudha Ramalingam; Thiagarajan Sairam; LS Somasundaram;
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作者单位

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年(卷),期 2016(10),2
年度 2016
页码 FC11–FC14
总页数 4
原文格式 PDF
正文语种
中图分类
关键词
Pioglitazone Pro12Ala Pharmacogenetic Glycaemic response South India;

机译：吡格列酮;Pro12Ala;药物发生;血糖反应;南印度;

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专利

1. Genotype Phenotype Correlation of Genetic Polymorphism of PPAR Gamma Gene and Therapeutic Response to Pioglitazone in Type 2 Diabetes Mellitus- A Pilot Study [J] . S. Shanmuga Priya, Ramalingam Sankaran, Sudha Ramalingam, Journal of Clinical and Diagnostic Research . 2016,第2期

机译：PPARγ基因多态性与2型糖尿病对吡格列酮治疗反应的基因型表型相关性
2. Genotype Phenotype Correlation of Genetic Polymorphism of PPAR Gamma Gene and Therapeutic Response to Pioglitazone in Type 2 Diabetes Mellitus- A Pilot Study [J] . S. Shanmuga Priya, Ramalingam Sankaran, Sudha Ramalingam, Journal of Clinical and Diagnostic Research . 2016,第2期

机译：PPARγ基因多态性与2型糖尿病对吡格列酮治疗反应的基因型表型相关性
3. IFIH1 gene polymorphisms in type 1 diabetes: Genetic association analysis and genotype-phenotype correlation in Chinese Han population [J] . YangH., WangZ., XuK., Autoimmunity . 2012,第3期

机译：1型糖尿病患者IFIH1基因多态性：中国汉族人群遗传关联分析及基因型-表型相关性
4. Association of Single Nucleotide Polymorphism and Phenotypes in Type 2 Diabetes Mellitus Using Genetic Algorithm and CatBoost [C] . Hilmi Farhan Ramadhani, Wisnu Ananta Kusuma, Lailan Sahrina Hasibuan, International Conference on Computer Science and Its Application in Agriculture . 2020

机译：应用遗传算法和CatBoost对2型糖尿病单核苷酸多态性与表型的关联
5. The associations between diet, flavonoids, polymorphisms of the PPAR-gamma, PPAR-delta, and CRP genes and lung and upper aerodigestive tract (UADT) cancers [D] . Burke, Rita Velikina. 2008

机译：饮食，类黄酮，PPAR-γ，PPAR-δ和CRP基因多态性与肺癌和上消化道消化道（UADT）癌症之间的关联
6. PPAR-γ2 and PTPRD gene polymorphisms influence type 2 diabetes patients response to pioglitazone in China [O] . Qi Pei, Qiong Huang, Guo-ping Yang, 2013

机译：PPAR-γ2和PTPRD基因多态性影响2型糖尿病患者对吡格列酮的反应
7. Genotype Phenotype Correlation of Genetic Polymorphism of PPAR Gamma Gene and Therapeutic Response to Pioglitazone in Type 2 Diabetes Mellitus- A Pilot Study [O] . S. Shanmuga Priya 2016

机译：基因型表型相关性PPARγ基因的遗传多态性与糖尿病2型糖尿杆菌的治疗反应 - 先导研究

Genotype Phenotype Correlation of Genetic Polymorphism of PPAR Gamma Gene and Therapeutic Response to Pioglitazone in Type 2 Diabetes Mellitus- A Pilot Study

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