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Intratumoral OH2 an oncolytic herpes simplex virus 2 in patients with advanced solid tumors: a multicenter phase I/II clinical trial

机译：肿瘤OH2一种溶血性疱疹病毒2在高级实体瘤患者中：多中心I / II临床试验

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摘要

OH2 is a genetically engineered oncolytic herpes simplex virus type 2 designed to selectively amplify in tumor cells and express granulocyte-macrophage colony-stimulating factor to enhance antitumor immune responses. We investigated the safety, tolerability and antitumor activity of OH2 as single agent or in combination with HX008, an anti-programmed cell death protein 1 antibody, in patients with advanced solid tumors.

机译：OH2是遗传工程的氯蛋白疱疹单纯乳糖型2型，设计用于在肿瘤细胞中选择性地扩增，表达粒细胞 - 巨噬细胞菌落刺激因子，以增强抗肿瘤免疫应答。我们研究了OH2作为单一剂的安全性，耐受性和抗肿瘤活性，或者与HX008组合，患有先进的实体瘤患者的抗程序化细胞死亡蛋白1抗体。

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期刊名称 Journal for Immunotherapy of Cancer
作者
Bo Zhang; Jing Huang; Jialin Tang; Sheng Hu; Suxia Luo; Zhiguo Luo; Fuxiang Zhou; Shiyun Tan; Jieer Ying; Qing Chang; Rui Zhang; Chengyun Geng; Dawei Wu; Xiangyong Gu; Binlei Liu;
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作者单位

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年(卷),期 2021(9),4
年度 2021
页码 e002224
总页数 10
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词

机译：溶瘤病毒;免疫疗法;临床试验作为主题;肿瘤微环境;

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专利

1. A phase I trial of intratumoral administration of recombinant oncolytic adenovirus overexpressing HSP70 in advanced solid tumor patients. [J] . Li JL, Liu HL, Zhang XR, Gene therapy . 2009,第3期

机译：在晚期实体瘤患者中瘤内施用过表达HSP70的重组溶瘤腺病毒的I期试验。
2. A phase I dose-escalation clinical trial of intraoperative direct intratumoral injection of HF10 oncolytic virus in non-resectable patients with advanced pancreatic cancer [J] . A Nakao, H Kasuya, T T Sahin, Cancer gene therapy . 2011,第3期

机译：不可手术切除的晚期胰腺癌患者术中直接瘤内注射HF10溶瘤病毒的I期剂量递增临床试验
3. A Phase I clinical trial of EUS-guided intratumoral injection of the oncolytic virus, HF10 for unresectable locally advanced pancreatic cancer [J] . Yoshiki Hirooka, Hideki Kasuya, Takuya Ishikawa, BMC Cancer . 2018,第1期

机译：EUS指导的瘤内注射溶瘤病毒HF10的I期临床试验用于不可切除的局部晚期胰腺癌
4. Vectorization in an Oncolytic Vaccinia Virus of Antibodies Against Programmed Cell Death -1 (PD-1) Allows Their Intratumoral Delivery and an Improved Tumor-Growth Inhibition [C] . Jean-Baptiste March, Patricia Kleinpeter, Laetitia Fend, Protein Engineering Summit. . 2018

机译：矢量化在抗体抗体的抗体疫苗病毒中，针对编程的细胞死亡-1（PD-1）允许其肿瘤内递送和改善的肿瘤生长抑制
5. Mechanisms of cell death initiated in herpes simplex virus thymidine kinase expressing colon tumor cells treated with ganciclovir and UCN-01. [D] . Ahn, Christina Elizabeth. 2005

机译：在用更昔洛韦和UCN-01处理过的单纯疱疹病毒胸苷激酶表达结肠肿瘤细胞中引发细胞死亡的机制。
6. A Phase I clinical trial of EUS-guided intratumoral injection of the oncolytic virus HF10 for unresectable locally advanced pancreatic cancer [O] . Yoshiki Hirooka, Hideki Kasuya, Takuya Ishikawa, 2018

机译：EUS指导的瘤内注射溶瘤病毒HF10的I期临床试验用于不可切除的局部晚期胰腺癌
7. Intratumoral Combinatorial Administration of CD1c (BDCA-1)+ Myeloid Dendritic Cells Plus Ipilimumab and Avelumab in Combination with Intravenous Low-Dose Nivolumab in Patients with Advanced Solid Tumors: A Phase IB Clinical Trial [O] . Julia Katharina Schwarze, Gil Awada, Louise Cras, 2020

机译：CD1C（BDCA-1）+骨髓树突状细胞的肿瘤组合施用与高级实体瘤患者中静脉内低剂量Nivolumab组合的IPILIMIMAB和Avelumab：IB期临床试验

Intratumoral OH2 an oncolytic herpes simplex virus 2 in patients with advanced solid tumors: a multicenter phase I/II clinical trial

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