Antenatal Selenium Deficiency Decreases Neonatal Pulmonary Selenium-Containing Antioxidant Enzymes

摘要

Bronchopulmonary dysplasia (BPD) is the most common complication of prematurity. Selenium (Se) deficiency increases the risk for oxygen requirement at 28 days and BPD and thus may be a modifiable nutritional intervention. Se is an essential trace mineral that is incorporated into Se-containing antioxidant enzymes (AOE). An infant's Se status at birth is regulated by the mother's Se supply during pregnancy, however, it is unknown if any neonatal Se-containing AOE in the lung are decreased by antenatal Se deficiency. We hypothesize that antenatal Se deficiency will decrease neonatal pulmonary expression of Se-containing AOE.