Factors contributing to good oocyte competence and utility rates for in vitro fertilization or intracytoplasmic sperm injection in high responders

摘要

To the Editor: The oocyte utility rate (OUR) describes the competence of oocytes to develop into usable embryos that can be transferred or cryopreserved. Except for maternal age, abnormalities due to intra-ovarian and/or extra-ovarian factors may affect the oocyte-granulosa cell interaction, maturation, and zygote development. In this study, we defined OUR as the number of applicable embryos (blastomere and blastocyst) divided by the number of oocytes retrieved from the corresponding stimulation cycle. We compared high and low OUR of cycles with at least 15 oocytes to determine the factors contributing to the huge gap between good and poor OUR to guide promising in vitro fertilization (IVF) outcomes.