EphB2 knockdown decreases the formation of astroglial‐fibrotic scars to promote nerve regeneration after spinal cord injury in rats

摘要

At the beginning of spinal cord injury (SCI), the expression of EphB2 on fibroblasts and ephrin‐B2 on astrocytes increased simultaneously and their binding triggers the formation of astroglial‐fibrotic scars, which represent a barrier to axonal regeneration. In the present study, we sought to suppress scar formation and to promote recovery from SCI by targeting EphB2 in vivo.