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Nano-Layered Dual Hydroxide-Biological Factor Combined System for Promoting Nerve Regeneration to Repair Spinal Cord Injury
Nano-Layered Dual Hydroxide-Biological Factor Combined System for Promoting Nerve Regeneration to Repair Spinal Cord Injury
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机译:纳米层双氢氧化物 - 生物因子组合系统,促进神经再生修复脊髓损伤
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摘要
Disclosed is a nano-layered dual hydroxide-biological factor combined system for promoting nerve regeneration to repair a spinal cord injury. The preparation method therefor comprises: 1) synthesizing a nano-layered dual hydroxide CL1; and 2) co-incubating 10 mg CL1 and 200-2000 ng of biological factors NT3, VEGF or bFGF in a low-speed shaker at 4° C. for 2 hours using an ion exchange method, centrifuging same and then obtaining the precipitate. Experiments on transection and resorption spinal cord injury models show that this combined system has a significant recovery effect on the behavior of model mice, can reconstruct the neural circuit of a damaged area over time and achieves an ideal repair effect with regard to a spinal cord injury.
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