A Double-Blind Randomized Control Trial of Rapidly Infused High Strong Ion Difference (SID) Fluid Versus Hartmann’s Solution on Acid-Base Status in Sepsis Patients in the Emergency Department

摘要

Balanced fluids are preferred in initial resuscitation of septic patients based on several recent studies. The Stewart’s concept on acid-base balance predicts that high strong ion difference (SID) fluid thus will increase the pH level. To date, the impact of high SID fluid in septic patient with metabolic acidosis remains uncertain. We conducted single center, randomized, double-blind trial to compare the effect of high SID fluid vs. Hartmann’s solution on acid-base status in selected sepsis patients in the Emergency Department.