SOX9 keeps growth plates and articular cartilage healthy by inhibiting chondrocyte dedifferentiation/osteoblastic redifferentiation

机译：SOX9通过抑制软骨细胞消除剂/骨细胞再分化来保持生长板和关节软骨健康

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期刊名称 Proceedings of the National Academy of Sciences of the United States of America
作者
Abdul Haseeb; Ranjan Kc; Marco Angelozzi; Charles de Charleroy; Danielle Rux; Robert J. Tower; Lutian Yao; Renata Pellegrino da Silva; Maurizio Pacifici; Ling Qin; Véronique Lefebvre;
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年(卷),期 2021(118),8
年度 2021
页码 e2019152118
总页数 11
原文格式 PDF
正文语种
中图分类
关键词

机译：软骨;细胞分化;谱系确定;SOX9;转录规则;

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专利

1. Induced Redifferentiation of Human Chondrocytes from Articular Cartilage Lesion in Alginate Bead Culture After Monolayer Dedifferentiation: An Alternative Cell Source for Cell-Based Therapies? [J] . Aurich Matthias, Hofmann Gunther O., Best Norman, Tissue engineering, Part A . 2018,第3a4期

机译：单层消除后藻酸盐珠培养的关节软骨病变中诱导人软骨细胞的重新化：用于细胞基疗法的替代细胞源？
2. TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages [J] . GaoL., SheuT.-J., DongY., Journal of Cell Science . 2013,第24期

机译：TAK1调节软骨细胞中的SOX9表达，并且对于生长板和关节软骨的出生后发育至关重要
3. CHONDROCYTE-SPECIFIC LOSS OF THE BRANCHED ACTIN MEDIATOR ARP2/3 RESULTS IN GROWTH PLATE FUSION AND PROTEOGLYCAN LOSS IN ARTICULAR CARTILAGE [J] . Diekman B. O., Rotty J. D., Ulici V., Osteoarthritis and cartilage . 2017,第Suppla1期

机译：细胞细胞特异性损失的分支肌动蛋白介质ARP2 / 3导致高音软骨中的生长型融合和蛋白多糖损失
4. Down-regulated cathepsin K expression inhibit chondrocytes dedifferentiation and enhance cartilage formation in vivo [C] . Jie Li, Yan Zhang, Guangdong Zhou, World biomaterials congress . 2012

机译：组织蛋白酶K表达下调抑制软骨细胞去分化并增强体内软骨形成
5. Electromechanical properties of normal cartilage and biomechanical regulation of transplanted chondrocytes: Implications for articular cartilage tissue engineering. [D] . Chen, Albert Chi-Shoung. 1997

机译：正常软骨的机电特性和移植软骨细胞的生物力学调节：对关节软骨组织工程的意义。
6. TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages [O] . Lin Gao, Tzong-jen Sheu, Yufeng Dong, -1

机译：TAK1调节软骨细胞中的SOX9表达并且对于生长板和关节软骨的出生后发育至关重要
7. Regulation of growth plate and articular chondrocyte differentiation : implications for longitudinal bone growth and articular cartilage formation [O] . Chau Michael 2014

机译：生长板和关节软骨细胞分化的调节：对纵向骨生长和关节软骨形成的影响

SOX9 keeps growth plates and articular cartilage healthy by inhibiting chondrocyte dedifferentiation/osteoblastic redifferentiation

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