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Infer HIV transmission dynamics from gene sequences among young men who have sex with men in China

机译:从与中国男性发生性关系的年轻人中的基因序列中推断出HIV传输动态

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摘要

To investigate the transmission dynamics and temporal and spatial migration characteristics of HIV spread among men who have sex with men (MSM) in China, a total of 1012 HIV-1 partial pol sequences, including five subtypes, were studied. Bayesian analysis were applied for each subtype to infer its dynamic characters including the effective reproductive number (Re) and migration process. The mean curve of each Re was almost always greater than 1 (even the 95% highest posterior density (HPD) lower value) along with time, which supports the necessity for a comprehensive study about risk behaviors among young MSM group in China. We also should reappraise the free treatment strategy, especially the therapeutic effect during the free treatment policy.
机译:为了研究与中国发生性关系的男性艾滋病病毒患者的传播动力学和时间和空间迁移特征,研究了1012名HIV-1部分POL序列,包括五个亚型。贝叶斯分析应用于每个子类型,以推断其动态字符,包括有效的生殖数字(RE)和迁移过程。每个RE的平均曲线几乎总是大于1(即使是最高后密度(HPD)的最高密度(HPD)较低)以及时间,这支持了中国年轻MSM集团中的风险行为综合研究的必要性。我们还应重新评估自由处理策略,特别是在自由处理政策期间的治疗效果。

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