Diagnostic and Prognostic Significance of miR-675-3p in Patients WithAtherosclerosis

摘要

In recent years, a rising number of studies have confirmed that microRNA (miRNA)plays a prominent role in the early diagnosis and prognostic value assessment ofcardiovascular diseases. The current study was conducted to examine theexpression of miR-675-3p in atherosclerosis (AS) patients and to evaluate itsclinical diagnosis and prognostic value. 110 AS patients and 70 healthy controlswere included in the study. Serum miR-675-3p levels were detected byquantitative real-time PCR (qRT-PCR). The clinical diagnostic significance ofserum miR-675-3p in AS patients were investigated by the receiver operatingcharacteristic (ROC) curve. The correlation between miRNA and carotidintima-media thickness (CIMT) was analyzed by the Spearman correlationcoefficient. The prognostic significance of serum miR-675-3p was evaluated bythe Kaplan-Meier method and Cox regression analysis. The patient’s serummiR-675-3p was significantly increased than the healthy individuals(P < 0.05). An increase of carotid intima-mediathickness (CIMT) was positively correlated with the promotion of serummiR-675-3p levels. The area under the ROC curve (AUC) was 0.918, with highsensitivity and specificity. miR-675-3p is a key independent predictor ofcardiovascular adverse events in AS patients (HR = 5.375, 95%CI = 1.590-18.170,P = 0.007), and patients with elevated miR-675-3p were morelikely to have cardiovascular adverse events (log-rank P =0.030). Increased miR-675-3p can be used as a potential marker for the diagnosisof AS, and was associated with the poor prognosis of AS.