Efficacy of a live attenuated highly pathogenic PRRSV vaccine against a NADC30-like strain challenge: implications for ADE of PRRSV

摘要

Vaccination and challenge strategies. At week 0, 4-week-old piglets were inoculated with attenuated PRRSV vaccine at the indicated dose via an intramuscular injection in accordance with the manufacturer’s instructions or with PBS as a mock-vaccination control (red stealth arrow). Then, A PRRSV strain HNhx challenge was then performed in the piglets of each group at the indicated week post-vaccination (black arrow). Sera and lung tissues were collected at her marked timepoints