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美国卫生研究院文献>BMJ Open Respiratory Research
>Examining the possible causal relationship between lung function COPD and Alzheimer’s disease: a Mendelian randomisation study
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Examining the possible causal relationship between lung function COPD and Alzheimer’s disease: a Mendelian randomisation study
Large retrospective case-control studies have reported an association between chronic obstructive pulmonary disease (COPD), reduced lung function and an increased risk of Alzheimer’s disease. However, it remains unclear if these diseases are causally linked, or due to shared risk factors. Conventional observational epidemiology suffers from unmeasured confounding and reverse causation. Additional analyses addressing causality are required.
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